With the growing availability and use of copper-based nanomaterials (Cu-NMs), there is increasing concern regarding their release and potential impact on the environment. In this study, the short-term (≤5 d) aging profile and the long-term (135 d) speciation of dissolved Cu, copper oxide, and copper sulfide nanoparticles (CuO-NPs and CuS-NPs) were investigated in five different soils using X-ra...

Following ingestion of radioactive copper by the dog, the metal appears quickly in the plasma, the concentration reaching its peak in from 2 to 5 hours, after which it falls abruptly. Demonstrable amounts are still present after 2 days. The radioactive copper likewise appears rapidly in the circulating red blood cells, and there is a slow but gradual increase in its concentration over a 2 day p...

Rat liver and horse kidney metallothioneins react with 5,5'-dithiobis-(2-nitrobenzoic acid) (Nbs2) to release 5-thio-2-nitrobenzoate and metal ions. The reactions are slow and exhibit biphasic kinetics with each process having an empirical rate law of the form: rate - k[RSM] X [Nbs2] + k'[RSM], where RSM represents mental-bound thiolate groups. The pseudo-first-order rates are insensitive to pH...

The Haber–Bosch process for the commercial production of ammonia demonstrated in 1913 was a watershed event in the mass production of urea, the principal nitrogen fertilizer for modern agriculture. Today, thanks to the so-called “green revolution” starting in in the 1960s, nearly half of the world population relies on increased crop yields, through the use of nitrogen fertilizers, to access aff...

Hydralazine has been used for the treatment of hypertension since 1950 (Gross et al., 1950), but only since the introduction of beta-adrenoceptor blocking agents has its use again become popular (Koch-Weser, 1976). Originally, hydralazine was given in four divided doses, but it has been shown to be equally effective and without increased side-effects when given by twice daily dosage (O'Malley e...

We report on the formation of hydrogel monoliths formed by functionalized peptide Fmoc-RGD (Fmoc: fluorenylmethoxycarbonyl) containing the RGD cell adhesion tripeptide motif. The monolith is stable in water for nearly 40 days. The gel monoliths present a rigid porous structure consisting of a network of peptide fibers. The RGD-decorated peptide fibers have a β-sheet secondary structure. We prov...

glycation is a protein modification, which results in a change in a protein structure. glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and alz-heimer’s disease (ad). activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progressi...

Metals are used in a variety of ways, many of which lead to dissipative releases to the environment. Such releases are relevant from both a resource use and an environmental impact perspective. We present a historical analysis of copper dissipative releases in the United States from 1975 to 2000. We situate all dissipative releases in copper's life cycle and introduce a conceptual framework by ...

Anthropogenic inventories for copper (229 ± 89 ug/cm2, N = 30), and mercury (470 ± 307 ng/cm2, N = 25) in Lake Superior sediments are much greater than inventories in remote lakes (Cu 50 ± 31 ug/cm2, Hg 64 ± 34 ng/cm2, N = 16) that receive inputs largely from long-distance atmospheric sources. Whereas the absolute concentration of mercury in Lake Superior sediments is not high (80–110 ng/g), en...