The consumption of a wide variety of substances determines, through different mechanisms, the onset of sleep disturbances, which has a considerable impact on the neurobiology of sleep-wake circadian rhythm. Many substances are widely used and easy to find, such as alcohol, nicotine and caffeine and are frequently the cause of degradation in quality and quantity of sleep. Furthermore, substance ...

BACKGROUND There is accumulating evidence that anxiety impairs sleep. However, due to high sleep variability in anxiety disorders, it has been difficult to state particular changes in sleep parameters caused by anxiety. Sleep profiling in an animal model with extremely high vs. low levels of trait anxiety might serve to further define sleep patterns associated with this psychopathology. METHO...

Sleep and wakefulness are governed by both the suprachiasmatic nuclei of the hypothalamus (SCN), and a sleep homeostatic process; however, the interaction of these control systems is not well understood. From rodent studies it has been assumed that the SCN promote neither wake nor sleep but gate the homeostatic sleep-promoting process. Yet in humans sleep tendency is lowest during the later wak...

Sleep in Drosophila shares many features with mammalian sleep, but it remains unknown whether spontaneous and evoked activity of individual neurons change with the sleep/wake cycle in flies as they do in mammals. Here we used calcium imaging to assess how the Kenyon cells in the fly mushroom bodies change their activity and reactivity to stimuli during sleep, wake, and after short or long sleep...

As well as in all medical disorders, taking the patient's history is very important in sleep medicine, too. Polygraphic studies, however, are indispensable and recording of sleep and wake gets a more and more important role in clinical neurophysiology. This chapter is meant to give an overview of technical aspects, how to perform recording and to give an estimate of the diagnostic yield of poly...

Introduction Sleep and migraine share a common pathophysiological substrate, although the underlying mechanisms are unknown. The serotonergic and orexinergic systems are both involved in the regulation of sleep/wake cycle, and numerous studies show that both are involved in the migraine etiopathogenesis. These two systems are anatomically and functionally interconnected. Our hypothesis is that ...

The majority of adults sleep with a partner, and for a significant proportion of couples, sleep problems and relationship problems co-occur, yet there has been little systematic study of the association between close relationships and sleep. The association between sleep and relationships is likely to be bi-directional and reciprocal-the quality of close relationships influences sleep and sleep...

background: premature birth is a major cause of infant mortality in developed countries. newborns confined to neonatal intensive care units (nicus) are in a rapid stage of brain development. as such, sleep plays a pivotal role in the proper brain development of newborns. however, this developmental aspect is often disregarded due to the lack of information. aim: this study aimed to evaluate the...

RATIONALE The concept of a tonic drive activating respiratory muscle in wakefulness but not sleep has been an important and enduring notion in respiratory medicine, not least because it is useful in modeling sleep effects on breathing and understanding the pathogenesis of sleep-related breathing disorders such as obstructive sleep apnea. However, a neurotransmitter substrate mediating respirato...