Objective: Much of the previous research on breakfast skipping and its associations with disordered eating, obesity, and depression has been limited by the use of different definitions “breakfast skipping.” The present study examines breakfast skipping and its associations with these negative health correlates in the Add Health Wave III sample of adolescents and young adults using all the defin...

Antisense-mediated exon skipping is currently in clinical development for Duchenne muscular dystrophy (DMD) to amend the consequences of the underlying genetic defect and restore dystrophin expression. Due to turnover of compound, transcript, and protein, chronic treatment with effector molecules (antisense oligonucleotides) will be required. To investigate the dynamics and persistence of antis...

The prevalence of overweight and obesity has increased globally, and population data suggest that it is also increasing among ethnic Fijian youth. Among numerous behavioural changes contributing to overweight in youth residing in nations undergoing rapid economic and social change, meal skipping has not been examined as a potential risk factor. The study objectives were to assess the prevalence...

As data volumes continue to grow, modern database systems increasingly rely on data skipping mechanisms to improve performance by avoiding access to irrelevant data. Recent work [39] proposed a fine-grained partitioning scheme that was shown to improve the opportunities for data skipping in row-oriented systems. Modern analytics and big data systems increasingly adopt columnar storage schemes, ...

The severe muscle wasting disorder Duchenne muscular dystrophy (DMD) is caused by genetic defects in the DMD gene, leading to a complete absence of dystrophin protein. Of the therapeutic approaches addressing the underlying genetic defect, exon skipping through antisense oligonucleotides (AONs) is the closest to clinical application. Several strategies to improve the efficiency of this approach...

The dystrophin gene is the largest gene in the human genome, and it codes for a protein which plays an important role in anchoring the cytoskeleton to the cell membrane. Mutations in the gene may cause Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD), an allelic variant. Currently genetic therapy holds great promise in finding a cure through exon skipping by restoring the pr...

Incited by public fascination and engineering application, water-skipping of rigid stones and spheres has received considerable study. While these objects can be coaxed to ricochet, elastic spheres demonstrate superior water-skipping ability, but little is known about the effect of large material compliance on water impact physics. Here we show that upon water impact, very compliant spheres nat...

Weshow that repulsive local Coulomb interaction alone can drive valence-skipping charge disproportionation in the degenerate d-band, resulting in effective negative-U . This effect is shown to originate from anisotropic orbitalmultipole scattering, and it occurs only for d1, d4, d6, and d9 fillings (and their immediate surroundings). Explicit boundaries for valence-skipping are derived, and the...

Germline mutations in the DNA mismatch repair genes MSH2 and MLH1 are responsible for the majority of hereditary nonpolyposis colorectal cancer (HNPCC) families. A common mutation mechanism is to disrupt MLH1 and MSH2 mRNA splicing. The disruption creates aberrant mRNAs lacking specific coding exons (exon skipping). Here, we report a novel skipping of MLH1 exon 12 caused by an AAG to TAG nonsen...

A readily available animal model is essential for rapidly identifying effective treatments for Duchenne muscular dystrophy (DMD), a devastating neuromuscular disorder caused by the lack of dystrophin protein, which results from frame-disrupting mutations in the DMD gene. Currently, the mdx mouse is the most commonly used model for antisense oligonucleotide (AO)-mediated exon skipping pre-clinic...