aim: benefits of skin-to-skin contact (ssc) between mother and her newborn, specifically when it is conducted immediately after birth, have been recognized for more than 40 years. to determine why ssc is not conducted, the present study considers the opinions of the labor working midwifes about the reinforcing factors in ssc immediately after birth in tehran's hospitals in 2012-2013. methods: i...

The skin is the largest tissue of man with several functions. Cosmetics/cosmeceuticals agents always are needed to be evaluated for their detrimental effects on the skin. Nowadays, the therapeutic potential of stem cells has and fibroblasts have increased the hope for a successful cell therapy in aesthetic medicine. Stem cells are unspecialized cells capable of renewing themselves through cell ...

Exposure of human skin to solar ultraviolet (UV) irradiation induces matrix metalloproteinase-1 (MMP-1) activity, which degrades type I collagen fibrils. Type I collagen is the most abundant protein in skin and constitutes the majority of skin connective tissue (dermis). Degradation of collagen fibrils impairs the structure and function of skin that characterize skin aging. Decorin is the predo...

Steroid 5α-reductase is the enzyme that converts testosterone to 5α-dihydrotestosterone (DHT). Two isoenzymes have been identified, namely type 1 and type 2 [1]. The conversion of testosterone to DHT is irreversible and the androgenic potency of DHT was shown to be at least 2–5 times stronger than that of testosterone [2, 3]. The hyperactivity of this enzyme is, therefore, supposed to play an i...

Advanced glycation end-products (AGEs), measured by skin autofluorescence (AF), are a factor in the development or worsening of many degenerative diseases, such as diabetes and atherosclerosis. Irisin levels have been associated with diabetes, endothelial dysfunction and atherosclerosis. The objective of the present study was to investigate whether circulating irisin levels are correlated with ...

Previous studies have suggested that procollagen types I and III are the major collagenous gene products of cultured human skin fibroblasts. In this study the expression of 10 different genes, encoding the subunit polypeptides for collagen types I-VI, by human skin fibroblasts in culture was analyzed by molecular hybridizations. Northern transfer analysis demonstrated the presence of specific m...

Introduction The first medical intervention for many breast cancer patients is breast conserving surgery (BCS) and/or modified radical mastectomy (MRM). Most of these patients undergo radiation therapy, following surgery. The most common side-effect of breast radiotherapy is skin damage. In the present study, the severity of acute skin changes and the underlying causes were investigated in pati...

Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such a...