Bioengineered organs raised in vitro are candidate substitutes for natural organs in biological, pharmacological and clinical applications. We have studied cell kinetics in a human skin equivalent (HSE) using a combined immunohistochemical and flow cytometric approach. Morphological analysis has shown that, relative to unstimulated natural skin, cell proliferation mainly occurs in the basal lay...

Skin homeostasis is maintained by controlling the balance between proliferation and differentiation of epidermal stem cells. The microenvironment, including extrinsic stresses, growth factors, soluble molecules, cell-ECM and cell-cell communications, plays an important role in cell fate determination in vivo and in vitro. In response to external signals, keratinocytes cooperate with other cell ...

Skin aging is influenced by two distinct processes: intrinsic and extrinsic aging. The latter regroups the external factors influencing skin aging, including cigarette smoke sun rays. While these factors, studied separately, are known to cause premature effects of their synergy have been poorly characterized. objective this project assess harmful impact on Healthy substitutes were produced acco...

BACKGROUND There are several options for replacement of the dermal layer in full-thickness skin defects. In this study, we present the surgical outcomes of reconstruction using acellular dermal substitutes by means of objective and subjective scar assessment tools. METHODS We retrospectively reviewed the medical records of 78 patients who had undergone autologous split-thickness skin graft wi...

The Cosmetic Ingredient Review Expert Panel assessed the safety of bis-diglyceryl polyacyladipate-2 and bis-diglyceryl polyacyladipate-1 as used in cosmetics, finding that these ingredients are safe in cosmetic formulations in the present practices of use and concentration. Both ingredients are lanolin substitutes and are reported to function in cosmetics as skin-conditioning agents--emollients...

© 2002 Kaiser Foundation Health Plan of Washington. All Rights Reserved. Back to Top Kaiser Foundation Health Plan of Washington Clinical Review Criteria Wound Care Treatments  Autologous Platelet Derived Wound Healing Factors for Non Healing Cutaneous Wounds (Procuren)  Electrical Stimulation and Electromagnetic Therapy  Low Frequency, Noncontact, Nonthermal Ultrasound Wound Therapy  Mag...

The use of fiberendoscopic video-assisted technique in facial rejuvenation is one of the most advances in aesthetic plastic surgery of the face. It substitutes the coronal incision without the necessity of skin resection and allows a vertical reposition of the mobile soft tissue of the midface in indicated cases. It can easily be done through a small incision of the scalp just behind the corona...

Tissue engineering and regenerative medicine aim to produce tissue substitutes to restore lost functions of tissues and organs. This includes cell therapies, induction of tissue/organ regeneration by biologically active molecules, or transplantation of in vitro grown tissues. This review article discusses advanced cell therapies that make use of scaffolds and scaffold-free approaches. The first...