نتایج جستجو برای: skin permeability rate

تعداد نتایج: 1179169  

Journal: :Environmental Health Perspectives 1984
P H Dugard M Walker S J Mawdsley R C Scott

To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. The appearance of ...

2002
Chrisita Ackermann

The permeability coefficients obtained by means of an infinite dose diffusion cell system with nude mouse skin in vitro were compared to the ether-water partition coefficients of the following compounds: glucose, urea, glycerol, thiourea, alkanols (methanol to octanol), hydrocortisone and hydrocortisone 21-n-alkyl esters (-acetate to -heptanoate). The permeability coefficients ranged from 1.0 x...

Journal: :Avicenna journal of medical biochemistry 2023

Background: The skin is the largest organ of body and provides main barrier between internal external environment. Assessment permeability critical importance for understanding predicting in vivo efficacy bioavailability bioactive phenolic compounds. Objectives: This study investigated relationship compounds using silico methods. Methods: Screening was performed on 475 randomly selected Molecul...

2014
Junho Won Jin Woo Park

Purpose: To assess the ability of radiofrequency (RF) microporation to promote trans-epidermal delivery of arbutin. Methods: To investigate the enhancing effect of RF microchannels on skin permeation of arbutin, in vitro skin permeability studies were performed with RF microporation-treated Hartley albino guinea pig skin using Franz diffusion cell system. Furthermore, improved depigmentation ef...

2015
Harsha Kathpalia Vandana Bhalla Patravale Komal Sharma

The aim of the present study was to prepare and evaluate different formulations of Diclofenac diethylammonium in microemulsion base with a view to enhance its permeability through the skin. Various o/w and w/o microemulsions of Diclofenac diethylammonium were prepared by the spontaneous emulsification methods. Isopropyl myristate was used as oil phase, Polyoxyethylenesorbitan monooleate and Sor...

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