Vitiligo is sometimes complicated with psoriasis, and more frequently, pigmentation or depigmentation arises after psoriatic lesion subsides. It not clear whether melanocyte function maintained in which characterized by keratinocyte proliferation, how melanin migration to keratinocytes affected, we will discuss the behavior of pigment cells psoriasis lesions. Melanin-containing were observed ma...

We performed epi-mode pump-probe imaging of melanin in excised human pigmented lesions and both hemoglobin and melanin in live xenograft mouse melanoma models to depths greater than 100 µm. Eumelanin and pheomelanin images, which have been previously demonstrated to differentiate melanoma from benign lesions, were acquired at the dermal-epidermal junction with cellular resolution and modest opt...

Since ages, the skin colour is an important issue for human race. Melanocyte abnormalities are mentioned during the fetal developmental stages in literature from ancient cultures. The deciding factor for the pigmentation is melanin. An old notion of melanocyte producing melanin is now obsolete. It is the epidermal unit which is responsible for the process of melanogenesis, production and distri...

Melanin protects the skin against DNA damage induced by direct absorption of sunlight's UV radiation. Yet, irradiating melanin in vitro or in cultured cells also generates active oxygen species such as superoxide, which can indirectly induce oxidative base lesions and DNA strand breaks. This photosensitization is greater for pheomelanin (yellow and red melanin) than for eumelanin (brown and bla...

Many skin-whitening compounds target tyrosinase because it catalyzes two rate-limiting steps in melanin synthesis. Although many tyrosinase inhibitors are currently available for a skin-whitening purpose, undesirable adverse effects are also reported. Thus, numerous efforts have been made to develop safer tyrosinase inhibitors from natural products. In line with this, we tested fifty flavonoids...

The ability to change coloration allows animals to modify their patterning to suit a specific function. Many freshwater fishes, for example, can appear cryptic by altering the dispersion of melanin pigment in the skin to match the visual background. However, melanin-based pigments are also used to signal dominance among competing males; thus colour change for background matching may conflict wi...