Bronchiolo-alveolar carcinoma with subcutaneous chest wall metastasis is a very rare presentation. A case of 36- year-old male with metastatic subcutaneous chest nodule of bronchiolo-alveolar carcinoma, diagnosed by fine needle aspiration cytology, is reported here. Cutaneous metastases are of diagnostic importance because they may be the first manifestation of an undiscovered internal malig...

More than five hundred chemically injured patients were admitted to the Labbafi-Nejad Medical Center in Spring of 1984. These patients were of two groups. The majority of patients had extensive skin burns, eye injuries as well as respiratory problems, and a second group of patients suffered mainly from neuromuscular and psychological problems. In this report, clinical manifestation and obs...

A solitary skin metastasis is a rare manifestation of papillary thyroid carcinoma (PTC). A 55-year-old woman presented with a movable subcutaneous nodule in her anterior neck for several months. Three years ago, she underwent total thyroidectomy and remnant ablation for classical PTC (pT3N0M0) and was under thyroxine suppression therapy without any evidence of recurrent disease. The subcutaneou...

Pralatrexate is a novel antifolate, which shows increased antitumor activity in human tumor xenograft studies in mice compared with methotrexate. We investigated the effects of pralatrexate in a patient with adult T-cell lymphoma/leukemia with significant skin involvement. Atypical lymphocytes in epidermal Pautrier microabscesses were positive for HTLV-1. After the patient presented with leukem...

Pruritus is the most common of all dermatological complaints. Although pruritus is usually due to a primary skin disease, it may be a manifestation of a systemic illness. The majority of causes can be diagnosed from the history and physical examination. Laboratory investigations are usually not necessary. Treatment should be directed at the underlying cause whenever possible.

Actinic keratosis represents the earliest manifestation of non-melanoma skin cancer. Because of their risk of progression to invasive squamous cell carcinoma, an earlier diagnosis and treatment are mandatory. Their diagnosis sometimes could represent a challenge even for expert dermatologists. Dermoscopy, confocal laser microscopy and optical coherence tomography could help clinicians in diagno...

Prolidase deficiency is a rare autosomal recessive disorder characterized by recurrent and nonhealing skin ulcers along with facial dysmorphism and mental retardation. We report a 13-year-old girl who has clinical manifestation of Proliodase deficiency. It is a very rare disorder and no such case has been reported so far from Pakistan.

Dermatophilosis is a bacterial skin infection and wet conditions like, raining and dipping predispose sheep to it. A great economic loss can be caused by this disease because of its effect on the quality of wool. In Iran (near Saveh), there was an outbreak of the disease in a herd and the clinical manifestation was different from that of typical dermatophilosis. Diffuse wide alopecic area accom...