SJS and TEN are variants of the same process, presenting as severe mucosal erosions with widespread erythematous, cutaneous macules or atypical targets. The cutaneous lesions often become confluent and show a positive Nikolsky sign and epidermal detachment. In SJS, epidermal detachment involves less than 10% of the total body skin area; transitional SJS-TEN is defined by an epidermal detachment...

in this manuscript, we prove some coupled fixed point theoremsfor two pairs of self mappings satisfying contractive conditions of integraltype in generalized metric spaces. we furnish suitable illustrative examples.in this manuscript, we prove some coupled fixed point theoremsfor two pairs of self mappings satisfying contractive conditions of integraltype in generalized metric spaces. we furnis...

Sjögren's syndrome (SjS) is a chronic autoimmune disease that mainly targets the salivary and lacrimal glands. It has been controversial whether anti-muscarinic type 3 receptor (α-M3R) autoantibodies in patients with SjS inhibit intracellular trafficking of aquaporin-5 (AQP5), water transport protein, leading to secretory dysfunction. To address this issue, GFP-tagged human AQP5 was overexpress...

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with seve...

BACKGROUND AND AIM The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy of Sjogren's syndrome (SJS) patients remain unsatisfactory. This study aimed to determine the prognostic value of circulating autoantibodies levels in SJS patients with peripheral neuropathy. METHODS Two hundred and fifty serological positive (either anti-Ro or anti-La positive) SJS pati...

In this paper, employing the common property ($E.A$), we prove a common fixed theorem for weakly compatible mappings via an implicit relation in Intuitionistic fuzzy metric space. Our results generalize the results of S. Kumar [S. Kumar, {it Common fixed point theorems in Intuitionistic fuzzy metric spaces using property (E.A)}, J. Indian Math. Soc., 76 (1-4) (2009), 94--103] and C. Alaca et al...

Pseudo Ricci symmetric real hypersurfaces of a complex projective space are classified and it is proved that there are no pseudo Ricci symmetric real hypersurfaces of the complex projective space CPn for which the vector field ξ from the almost contact metric structure (φ, ξ, η, g) is a principal curvature vector field.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are both rare but serious idiosyncratic drug reactions characterized by diffuse muco-epidermoid injury and high mortality. Keratinocytes in both skin and mucous membranes (including eyes, mouth and genitalia) are injured resulting in a diffuse maculopapular rash, blistering lesions and epithelial detachment with minimal force (...

BACKGROUND Skin lesion is the most frequent manifestation of adverse drug reactions. Drug-induced cutaneous hypersensitivity and drug-induced acute interstitial nephritis might share a similar mechanism involving drug-specific T cells. We thus investigated the renal outcome of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the most severe drug-induced cutaneous hypersensit...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug hypersensitivities with high mortality. Typical over-the-counter drugs of cold medicines are suggested to be causative. As multiple ingredients are generally contained in cold medicines, it is of particular interest to investigate which ingredients are responsible for SJS/TEN. However, experimental examination o...