As Heftmann, Bennett, and Bonner have indicated (l), considerable information has accumulated concerning the biosynthesis of sterols in animals (2) and fungi (3), yet practically nothing is known about the biogenesis of typically higher plant sterols or the numerous pentacyclic triterpenes that are widely distributed throughout the plant kingdom. As yet, it cannot be assumed that the over-all b...

Changes in the balance of cholesterol absorption and synthesis and moderately elevated plasma plant sterols have been suggested to be atherogenic. Measuring cholestanol, lathosterol, campesterol, and sitosterol, we investigated the relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease (CAD) in 2,440 participants of the Ludwigshafen Risk an...

Gallic acid (GA), rutin(R), quercitin (Q), ellagic acid (EA) and sitosterol(S) isolated from the methanolic extract of the leaves of Tectona grandis were formulated as 0.2 % ointment in emulsifying base and were evaluated for their wound healing activity. The animals were divided into eight groups of six animals each. Groups 1 used as control, group 2 used as a standard i.e. nitrofurazone ointm...

Subjects with increased cholesterol absorption might benefit more from statin therapy combined with a cholesterol absorption inhibitor. We assessed whether baseline cholesterol absorption markers were associated with response to ezetimibe/simvastatin therapy, in terms of LDL-cholesterol (LDL-C) lowering and cholesterol absorption inhibition, in patients with familial hypercholesterolemia (FH). ...

The structural features of sterols required to support mammalian cell growth have not been fully defined. Here, we use mutant CHO cells that synthesize only small amounts of cholesterol to test the capacity of various sterols to support growth. Sterols with minor modifications of the side chain (e.g., campesterol, beta-sitosterol, and desmosterol) supported long-term growth of mutant cells, but...

The phytochemical investigation of an aqueous ethanolic extract of Galinsoga parviflora Cav. (Asteraceae) resulted in the isolation and identification of eleven compounds namely: triacontanol, phytol, beta-sitosterol, stigmasterol, 7-hydroxy-beta-sitosterol, 7-hydroxystigmasterol, beta-sitosterol-3-O-beta-D-glucoside, 3,4-dimethoxycinnamic acid, protocatechuic acid, fumaric acid, and uracil. Fu...

Pneumolysin is one of the major virulence factors elaborated by Streptococcus pneumoniae; this toxin is a member of the cholesterol-dependent cytolysins. Engagement of cholesterol induces the formation of a multi-subunit complex by pneumolysin that lyses host cells by forming pores on the membrane. Because pneumolysin released by bacteria which have been killed by conventional antibiotics is st...

Polyprenols separated from lipids are promising new components from Ginkgo biloba L. leaves (GBL). In this paper, ginkgo lipids were isolated by extraction with petroleum ether, saponification, and molecular distillation. Eight known compounds: isophytol (1), nerolidol (2), linalool (3), β-sitosterol acetate (4), β-sitosterol (5), stigmasterol (6), ergosterol (7), β-sitosterol-3-O-β-D-glucopyra...

The fecal excretion of cholesterol-4-(14)C and -sitosterol-22,23-(3)H has been studied in normal human subjects after they had ingested a single meal containing the radioactive substances. When 150 mg of -sitosterol, dispersed in the butter of a standard breakfast, was fed to 20 subjects the mean recovery of isotope in the feces was 90%. When plant sterols (70% -sitosterol, 30% campesterol) wer...

Four phytoecdysteroids: (20-hydroxyecdysone-20, 22-monacetonide (1), 20-hydroxyecdysone (2), stigmasterol (3), gamma-sitosterol (4), were investigated for toxic effect against 3 rd /4 th instar larvae of Anopheles gambiae under laboratory conditions as individual compounds and in blends. The test larvae were treated with solutions containing the phytoecdysteroids of concentrations 1, 5 and 10pp...