This paper discusses the use of small pixels in a spinning CdZnTe single photon emission computed tomography (SPECT) camera that is mounted with a parallel slat collimator. In a conventional slat collimation configuration, there is a detector pixel between two adjacent collimator slats. In our design, the pixel size is halved. That is, there are two smaller pixels to replace a regular pixel bet...

Fourteen children with various seizure disorders were studied using a cerebral blood flow tracer, 123I iodoamphetamine (0.05 mCi/kg), and single photon emission computed tomography (SPECT). In the five patients with radiological lesions, SPECT showed congruent or more extensive abnormalities. Five of the nine children with a normal scan on computed tomography had abnormal SPECT studies consisti...

The authors present a new method to compensate for the spatially variant detector response in single photon emission computed tomography (SPECT) with varying focal-length fan-beam (VFF) geometry. In this method, the deblurred projection is explicitly expressed as an integral of the collimator blurred data and the fully calibrated system kernel matrix with certain transforms. It needs a little m...

Background Myocardial salvage is an important surrogate endpoint assessing the success of coronary reperfusion in acute myocardial infarction. Single photon emission computed tomography (SPECT), the established modality for assessment of myocardial salvage, is logistically demanding and associated with a considerable radiation exposure. The combination of T2 and late-enhancement imaging in card...

Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [111In]-Liposome as a drug delivery vehicle, encapsulating a novel 18F-labeled carboplatin drug derivative ([18F]-FCP) as a dual-molecular imaging tool as bot...

Emission tomography provides three-dimensional, quantitative images of the distribution of radiotracers used to mark physiological, metabolic, or pathological processes. Quantitative single photon emission computed tomography (SPECT) requires correction for the image-degrading effects due to photon attenuation and scatter. Phantom experiments have shown that radioactive concentrations can be as...

Penalized maximum likelihood methods are commonly used in positron emission tomography (PET) and single photon emission computed tomography (SPECT). Due to the fact that a Poisson data-noise model is typically assumed, standard regularization parameter choice methods, such as the discrepancy principle or generalized cross validation, can not be directly applied. In recent work of the authors, r...

Over the past decade, quantitation of cardiac single-photon emission computed tomography (SPECT) data, once limited to perfusion assessment, has been extended to global and regional function assessment for both the left and the right ventricle, as well as to measurement of additional cardiac parameters of diagnostic and prognostic interest. A number of commercially available quantitative algori...

Monte Carlo simulations are nowadays an essential tool in emission tomography (Single-Photon Emission Computed Tomography— SPECT and Positron Emission Tomography—PET), for assisting system design and optimizing imaging and processing protocols. Several Monte Carlo simulation software are currently available for modeling SPECT and PET configurations. This paper presents an overview of current tr...

Accurate epileptic focus localization using single photon emission computed tomography (SPECT) images has proven to be a challenging endeavor. First, commonly used radiopharmaceuticals such as hexamethylpropylene amine oxime (HMPAO) quantitatively underestimate large blood flows, leading to subtracted SPECT images that do not reflect the true cerebral physiological conditions, and often display...