Purpose: Estrogen as a crucial hormone during pregnancy acts by two types of receptors.   Estrogen receptor alpha, expressed by estrogen receptor 1 (ESR1) gene, is more abundant and   exists in all human reproductive systems. Association of ESR1 gene polymorphism has been   shown in some reproductive fields such as spontaneous abortion, endometriosis-related infertility   and in vitro fertili...

Background: CDKN2A, encoding two important tumor suppressor proteins p16 and p14, is a tumor suppressor gene. Mutations in this gene and subsequently the defect in p16 and p14 proteins lead to the downregulation of RB1/p53 and cancer malignancy. To identify the structural and functional effects of mutations, various powerful bioinformatics tools are available. The aim of this study is the ident...

Ramie (Boehmeria nivea L.) bast fiber is one of the most ancient natural fibers, which used for textile only after degumming. Hemicellulose, pectin, and hydrotrope are main colloidal matters in ramie fiber, removed when However, genetic variation control loci poorly understood. Here, we analyzed discovered favorable single nucleotide poly morphisms (SNP) by genome-wide association study using 3...

Resistance to soybean rust (SBR), caused by Phakopsora pachyrhizi Syd. & Syd., has been identified in many soybean germplasm accessions and is conferred by either dominant or recessive genes that have been mapped to six independent loci (Rpp1 -Rpp6), but No U.S. cultivars are resistant to SBR. The cultivar DT 2000 (PI 635999) has resistance to P. pachyrhizi isolates and field populations from t...

Scope Poly-pharmacological therapy shapes the gut microbiota (GM) in metabolic syndrome (MetS) patients. The effects of polyphenols poly-medicated MetS patients are unknown. Methods and results A randomized, placebo-controlled, double-blinded, crossover trial (n=50) explored whether a pomegranate extract nutraceutical (PE, 320 mg phenolics/day for 1 month) affected by drug therapy. Considering ...

Microarrays are widely used to evaluate gene expression at the genome scale. However, all too often the importance of data analysis at the level of the individual probe is overlooked. This is a particular problem when trying to detect differences in gene expression levels among genetically unique animals, across inbred animal strains, or among genetically modified animals. Of particular concern...