There has been an increased focus on the relationship between health technology assessment (HTA) and regulatory assessments and how regulatory, HTA and coverage bodies, and industry can work better together to improve efficiency and alignment of processes. There is increasingly agreement across sectors that improved communication and coordination could contribute to facilitating timely patient ...

National Grid, UK is currently under the process of replacing the conventional high impedance (HiZ) busbar protection systems in their substations with modern low impedance (LI) numeric busbar protection schemes. They are also planning to deploy the same schemes in their new substations and substation extensions. This calls for an extensive changeover from the conventional operation, protection...

BACKGROUND Inappropriate quality management of reverse transcription-PCR (RT-PCR) assays for the detection of blood-borne prostate cancer (PCa) cells hampers clinical conclusions. Improvement of the RT-PCR methodology for prostate-specific antigen (PSA) mRNA should focus on an appropriate numeric definition of the performance of the assay and correction for PSA mRNA that is not associated with ...

Objectives: Physical therapy (PT) following shoulder surgery has traditionally occurred via in-office supervised visits. Recently digital health tools with remote patient monitoring (RPM) have emerged as an option to enhance the ability both monitor and encourage engagement of home PT. The appeal such been accelerated by impact COVID-19 on healthcare system. primary purpose this study was compa...

PURPOSE To contribute data to conceptual explorations of the role of institutional culture in promoting research ethics and integrity. METHOD The authors highlight relevant themes that emerged from a multimodal needs assessment conducted under the Johns Hopkins Clinical Translational Science Award regarding ethical issues encountered in the conduct of clinical and translational research. Qual...

Dietary exposures of great horned owls (GHO; Bubo virginianus) to polychlorinated biphenyls (PCBs) in the terrestrial food web at the Kalamazoo River, Michigan, USA, were examined. Average potential daily doses (APDD) in GHO diets were 7- to 10-fold and 3-fold greater at the more contaminated location versus a reference location for site-specific exposures quantified as total PCBs and 2,3,7,8-t...

the objective of this study was to diagnose integrative ecological health of an urban stream,which is located in the asian temperate region. the research approach was primarily based on the index ofbiological integrity (ibi) using fish assemblage and a qualitative habitat evaluation index (qhei). and these indexes were compared with long-term conventional chemical dataset during 1996-2005. for ...

A framework for integrated design of process and operation is proposed for metal-degreasing process in metal processing. In metal degreasing, a significant amount of cleansing agents is released to the environment, and local risks and global impacts originated in the cleansing agents have been crucial issues. The framework enables the engineers on site to perform rigorous risk assessments by us...

Health impact assessment (HIA) can ensure that health is a core element of sustainable urban planning. Based on the experience of the NSW HIA Project, we discuss the current strengths of HIA and challenges facing it as an urban sustainability tool across five areas: the use of evidence; integrating HIA with environmental impact assessments; including consideration of equity; recognising wider d...