Replication of alphaviruses in vertebrate cells strongly affects cell physiology and ultimately leads to development of a cytopathic effect (CPE) and cell death. Sindbis virus (SIN) replication causes major changes in cellular macromolecular synthesis, in which the strong downregulation of transcription of cellular mRNAs and rRNAs plays a critical role. SIN nonstructural protein nsP2 was previo...

Motion of a biharmonic system under action of small periodic force and small damped force is studied. The biharmonic oscillator is a physical system acting under a biharmonic force like a sin θ b sin 2θ. The article contains biharmonic oscillator analysis, phase space research, and analytic solutions for separatrixes. The biharmonic oscillator performs chaotic motion near separatrixes under sma...

Timing of cell division is coordinated by the Septation Initiation Network (SIN) in fission yeast. SIN activation is initiated at the two spindle pole bodies (SPB) of the cell in metaphase, but only one of these SPBs contains an active SIN in anaphase, while SIN is inactivated in the other by the Cdc16-Byr4 GAP complex. Most of the factors that are needed for such asymmetry establishment have b...

Sinomenine (SIN) is a bioactive alkaloid extracted from the Chinese medicinal plant Sinomenium acutum, which is widely used in the clinical treatment of rheumatoid arthritis (RA). However, its role in acute lung injury (ALI) is unclear. In this study, we investigate the role of SIN in lipopolysaccharide (LPS)-induced ALI in mice. After ALI, lung water content and histological signs of pulmonary...

One of the most recent solved problem of the theory of hamiltonian dynamical systems with two degrees of freedom is finishing a proof of the exponentially small transversality of the separatrices for the standard map ([1], [2], [3], [4]). The central point if the proof is a construction of an analytic integral along the unstable separatrix. Only the article [4] contains the complete evidence of...

We present predictions of a relatively simple model of the low-lying 0+ states in 12Be, their predicted energy splitting in 12O, their cross-section ratios in 10Be(t,p) and 14C(p, t) and their decay widths. Comparison is made with predictions using earlier wave functions of Barker. Disciplines Physical Sciences and Mathematics | Physics Comments Suggested Citation: Fortune, H.T. and Sherr, R. (...

W oter an Att eeldt Wouter van Atteveldt http://vanatteveldt.com http://content-analysis.org Semantic Network Analysis is a technique in which the content of a message (such as a newspaper article) is extracted from text and represented as a network of semantic relations between actors and issues, which can be queried to look for specific patterns and answer various research questions. This tec...