I knew something was up when I saw my daughter shouting at our computer , scolding one of her Sims—a simulated male who kept making a mess of his house. To undo the damage , my exasperated daughter had to give him specific and detailed cleaning instructions. Just like a guy! Yet hers must have been the sort of reaction Will Wright dreamt of when he first settled on the concept of The Sims sever...

Author's abstract Vesico-vaginalfistula (VVF) was a common ailment among American women in the 19th century. Prior to that time, no successful surgery had been developed for the cure of this condition until DrJ Marion Sims perfected a successful surgical technique in 1849. Dr Sims usedfemale slaves as research subjects over a four-year period of experimentation (1845-1849). This paper discusses...

Cherts are used to reconstruct the evolution of seawater δ18O and temperature over geological time. However, given influence marine diagenesis, reconstructing from isotope composition cherts is not straightforward, resulting in ambiguity interpretation. Here, we present a detailed petrographic investigation deep-sea drilled 135–40 Ma with focus on effects diagenesis. We combined triple O-isotop...

In this paper, we show that the consistency of closed-loop subspace identi cation methods (SIMs) can be achieved through innovation estimation. Based on this analysis, a su cient condition for the consistency of a new proposed closed-loop SIM is given, A consistent estimate of th Kalman gain under closed-loop conditions is also provided based on the algorithm. A multi-input-multi-output simulat...

Single Index Models (SIMs) are simple yet flexible semiparametric models for machine learning, where the response variable is modeled as a monotonic function of a linear combination of features. Estimation in this context requires learning both the feature weights and the nonlinear function that relates features to observations. While methods have been described to learn SIMs in the low dimensi...

Structured illumination microscopy (SIM) improves resolution by down-modulating high-frequency information of an object to fit within the passband of the optical system. Generally, the reconstruction process requires prior knowledge of the illumination patterns, which implies a well-calibrated and aberration-free system. Here, we propose a new algorithmic self-calibration strategy for SIM that ...

Single Index Models (SIMs) are simple yet flexible semi-parametric models for classification and regression. Response variables are modeled as a nonlinear, monotonic function of a linear combination of features. Estimation in this context requires learning both the feature weights, and the nonlinear function. While methods have been described to learn SIMs in the low dimensional regime, a metho...

We report an analysis method to identify conjugated ligands and their binding states on semiconductor nanocrystals based on their molecular information. Surface science techniques, such as time-of-flight secondary-ion mass spectrometry (ToF-SIMS) and FT-IR spectroscopy, are adopted based on the micro-aggregated sampling method. Typical trioctylphosphine oxide-based synthesis methods of CdSe/ZnS...