HYPOTHESES Goiter is a surgically reversible cause of positional dyspnea (PD). Substernal tracheal compression (TC) predicts PD relief after thyroidectomy (Tx). DESIGN Retrospective analysis of a prospective structured management algorithm. SETTING Endocrine surgery academic center. METHODS Before Tx, 1081 patients were queried about PD. Those patients with substernal goiter underwent com...

CONTEXT We studied two families from Galicia (northwest Spain) with Pendred syndrome (PS) and unusual thyroid phenotypes. In family A, the proposita had a large goiter and hypothyroxinemia but normal TSH and free T3 (FT3). In family B, some affected members showed deafness but not goiter. OBJECTIVE Our objective was to identify the mutations causing PS and molecular mechanisms underlying the ...

BACKGROUND Retrosternal goiter is defined as a thyroid mass of which more than 50% is located below the thoracic inlet. The aim of this study is to assess the retrosternal goiter surgically approach through a neck incision and analyze the surgical technique. CASE PRESENTATION The case reported by us used a single neck collar-shaped incision for huge retrosternal goiter with good outcome. The ...

INTRODUCTION We present a case of ectopic intrathoracic multinodular goiter and correlate the magnetic resonance imaging appearance with the histological findings. CASE PRESENTATION A 72-year-old man was referred to our institute with a two month history of cough. The chest radiograph showed a mass located in the mediastinum. A chest computed tomography scan, showed an enhancing mass at the r...

Intrathoracic goiters are usually located anteriorly, in the superior or anterior mediastinum, and are termed substernal or retrosternal goiters. Posterior mediastinal goiters are rare, about 10% of all intrathoracic goiters. Patients with retrosternal goiter usually have a visible or palpable cervical mass. In addition, tracheal deviation may be present with compression symptoms. Posterior med...

We analyzed the thyroglobulin (Tg) gene of 2 unrelated patients with congenital goiter and the Tg gene of 2 siblings with the variant type of adenomatous goiter. The clinical characteristics of the patients with congenital goiter and the variant type of adenomatous goiter were very similar, except for serum Tg levels, which were less than 15 pmol/L in the patients with congenital goiter, but 11...

Respiratory tract obstruction is underestimated in asymptomatic intrathoracic goiter. Our aim was to evaluate the involvement of the upper airway of asymptomatic patients with intrathoracic multinodular goiter, assessing the effect on respiratory function by means of spirometry. We selected 21 patients with asymptomatic intrathoracic goiter on whom a thyroidectomy had been performed. Spirometry...

The main objective of this study was to assess the iodine nutritional status among school children (6-12 yrs) of Sundarban delta in North 24-Parganas district of West Bengal in eastern India. A total of 2050 children were clinically examined for goiter and 240 urine samples were analyzed for iodine and thiocyanate respectively; iodine content in 48 water samples and 210 salt samples were also m...

Surgical removal of intrathoracic goiter can be performed by a cervical approach in the majority of patients. Review of literature shows that experienced surgeons need to perform an extracervical approach in 2-3% of cases. In spite of surgical management of substernal goiter is well defined, there is little available information about surgical approach of intrathoracic goiters extending beyond ...

Objective: Nodular goiter is the commonest lesion of thyroid gland. This study was carried out to see histopathological pattern of thyroid enlargement. Methodology: All thyroid lesions received in the Department of Pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre Karachi, over a period of five years were reviewed and relevant special stains were performed. Results...