Silymarin, an extract from seeds of Silybum marianum, is used by 8 to 33% of patients to self-treat chronic viral hepatitis C in the United States. Studies in humans and rodents suggest that biliary excretion of glucuronide and sulfate conjugates is the major route for silymarin's elimination. To determine the role of multidrug resistance-associated protein 2 (Mrp2) (Abcc2) in the biliary excre...

Silymarin is an over the counter food supplement that is sold as a liver enhancement and liver protection preparation. It is a major constituent of the seeds of Silybum marianum which is composed of a mixture of seven major components and several minor compounds. The seven major components: taxifolin, silychristin, silydianin, silybin A, silybin B, iso-silybin A and iso-silybin B were isolated ...

Many aldehydes are important components of natural flavours. They are used in food, cosmetic, and biomedical industries in large amounts. Plant cells or microorganisms carry out their production by biotransformation, which is one of the biotechnological methods that allow them to be defined as 'natural'. Cell cultures of Silybum marianum and Peganum harmala have been studied with a view to in...

BACKGROUND Berberine is an isoquinoline alkaloid widely used to improve the glucidic and lipidic profiles of patients with hypercholesterolemia, metabolic syndrome, and type 2 diabetes. The limitation of berberine seems to be its poor oral bioavailability, which is affected by the presence, in enterocytes, of P-glycoprotein - an active adenosine triphosphate (ATP)-consuming efflux protein that ...

The aim of this study was to evaluate the efficacy and safety of an anti-hypercholesterolemic agent containing Berberis aristata, Silybum marianum and monacolin K and KA in a sample of Caucasian patients at low cardiovascular risk according to Framingham score. The primary outcome was to evaluate the effects of this nutraceutical combination on lipid profile; the secondary outcome was to evalua...

This work is devoted to the study of effect Ilex paraguariensis decoction for energy and carbohydrate metabolism in conditions increased physical activity, analysis stabilisation possibilities liver injury lipid peroxidation markers rats an experimental model chronic alcohol intoxication. It’s established that I. exhibits antioxidant hepatoprotective effects with alcoholic liver, comparable act...

In this study, the effect of vermicompost and mycorrhizal fungi was investigated on growth, yield, chlorophyll pigments, leaf antioxidant enzymes, and seed silibinin content of Silybum marianum, milk thistle. The seeds were inoculated by two species of mycorrhiza fungi, Glomus mosseae and G. intraradices, and plants were irrigated and treated with 0, 25, 50, and 75% vermicompost after culturing...