نتایج جستجو برای: silybin

تعداد نتایج: 527  

A Mehrafarin , H Naghdi Badi , MR Labbafi , N Qavami ,

Milk thistle (Silybum marianum (L.) Gaertn.) is one of the valuable medicinal plants which used in the treatment of liver disorders. The major active constituents in this plant are flavonolignans, collectively known as silymarin which is a mixture of three isomer silybin, silydianin and silycristin. Its therapeutic properties are due to the presence of silymarin. The seeds contain the highest a...

Journal: :International journal of pharmaceutics 2014
Ruggero Angelico Andrea Ceglie Pasquale Sacco Giuseppe Colafemmina Maria Ripoli Alessandra Mangia

Among various phospholipid-mediated drug delivery systems (DDS) suitable for topic and oral administration, phytosome technology represents an advanced innovation, widely used to incorporate standardized bioactive polyphenolic phytoconstituents into phospholipid molecular complexes. In order to extend their potential therapeutic efficiency also to other routes of administration, we proposed a n...

Journal: :the iranian journal of pharmaceutical research 0
mahdi mashhadi akbar boojar department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. shahram ejtemaei mehr department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. mahsa hassanipour department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. masoud mashhadi akbar boojar department of cell and molecular biology, faculty of biological sciences, kharazmi university,tehran, iran. ahmad reza dehpour department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

ceramide as a second messenger is a key regulator in apoptosis and cytotoxicity. ceramide-metabolizing enzymes are ideal target in cancer chemo-preventive studies. neutral sphingomyelinase (nsmase), acid ceramidase (acdase) and glucosyl ceramide synthase (gcs) are the main enzymes in ceramide metabolism. silymarin flavonolignans are potent apoptosis inducers and silibinin is the most active com...

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