Intervention: Six 90 minute weekly sessions of individual cognitive behavioural therapy, specifically addressing hypochondriasis and including educational information, or usual care. To coordinate medical management with cognitive behavioural therapy, letters were sent to the participants’ practioners, advising them to be conservative in diagnosis and treatment, schedule regular appointments, m...

The effect of sucralfate on the bioavailability of ciprofloxacin was evaluated in eight healthy subjects utilizing a randomized, crossover design. The area under the concentration-time curve from 0 to 12 h was reduced from 8.8 to 1.1 micrograms.h/ml by sucralfate (P less than 0.005). Similarly, the maximum concentration of ciprofloxacin in serum was reduced from 2.0 to 0.2 micrograms/ml (P less...

BACKGROUND The prevalence of prehypertension has increased in China, and prehypertension frequently progress to hypertension over a short time period; both have become public health problems. Therefore, this study was conducted to determine the relationship between the Visceral Adiposity Index (VAI) and blood pressure (BP) in China. METHODS A cross-sectional epidemiological survey was conduct...

The main particle identification devices of the PANDA experiment will be two DIRCs placed around (barrel) and downstream (disc) of the target. The preferred photon sensor option are microchannel plate (MCP) PMTs because they can be operated inside the 2 Tesla magnetic field of the solenoid. Furthermore, these multi-anode sensors are rather compact and show a superior time resolution which is ty...

The time delay between the formation of a population of stars and the onset of type Ia supernovae (SNe Ia) sets important limits on the masses and nature of SN Ia progenitors. Here we use a new observational technique to measure this time delay by comparing the spatial distributions of SNe Ia to their local environments. Previous work attempted such analyses encompassing the entire host of each...

Vitronectin (Vn), a multifunctional adhesive protein, is found in association with tumor progression, angiogenesis and metastasis in a variety of (human) tumors. But no studies concerning its correlation to osteosarcoma prognosis were found. Hence, we aimed to investigate the prognostic value of Vitronectin (Vn) in osteosarcoma. Here, we studied the expression of VN in the tumor tissues from 67...

When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

Citrullination, a posttranslational modification of peptidyl arginine to citrulline, plays an essential role in rheumatoid arthritis (RA). Citrullination is catalyzed by a group of peptidylarginine deiminases (PADs) including PADI 1, 2, 3, 4 and 6. Many studies have indicated that the gene encoding PADI4 is a factor in susceptibility to RA. Some studies have detected PADI2 expression in RA syno...

Breast cancer remains one of the leading causes of cancer deaths among women.[1] Simple mastectomy is a common surgical procedure that is used in the management of breast cancer. Seroma is one of the most frequently encountered complications following mastectomy and is a serous fluid that accumulates in the space between the skin flap and underlying tissues. It may cause significant morbidity, ...