The determination of glycosylated hemoglobin (GHb) has been found useful in the medium term assessment of diabetic control. Levels of GHb have been shown to be influenced by hematological abnormalities and methodology amongst other factors. Hemoglobinopathies are common in Nigerians and other people of African descent. No work, to our knowledge, has been done in Nigeria to study the effect of h...

A renal tubular epithelial antigen (RTE)--anti-RTE autologous immune complex nephritis associated with sickle cell anaemia (SS) has been reported, but immune complex nephritis has never been described in patients with sickle cell trait (SA). During investigation of a child with "asymptomatic proteinuria" cryoprecipitable complexes of RTE-anti-RTE were detected in the serum and granular deposits...

he sickle cell hemoglobinopathy is a major public health problem in some parts of the world. Hemoglobin S is the most common clinically significant variant Hb. Hemoglobin S is most common in Africa, Kingdom of Saudi Arabia, Bahrain and the Mediterranean Basin.1 Sickle cell trait (HbAS) results in no detectable abnormality under normal circumstances although it is easily diagnosed by specific in...

Introduction: The Hemoglobinopathies are one of the major public health problems in tribal predominant population. Objective: To estimate the seroprevalence of Sickle Cell Anemia and Thalassemia in suspected cases of genetic disorders by using HPLC retention time chromatogram method in tribal predominant population, Ranchi, Jharkhand. Methods: All Blood sample of suspected cases of genetic diso...

URING the past fifteen years, data on the frequency of the sickle cell D gene have accumulated to such an extent that its world distribution can now be outlined in considerable detail. Frequencies of more than 20 percent of ‘the sickle cell trait have been found in populations across a broad belt of tropical Africa from the Gambia to Mozambique. Similar high frequencies have been found in Greec...

Restriction endonuclease analysis was used to test a proposed genetic model using alpha-globin gene number to account for the observed distributions of the proportions of hemoglobin (Hb) S in sickle cell trait. In a subsample of specimens collected during a population survey in India, these studies confirmed that the postulated genotype was present in 22 of the 23 individuals examined. In the s...

We describe the complex presentation of a patient with renal medullary carcinoma, a newly described entity primarily affecting young patients with sickle cell trait. Renal medullary carcinoma is an aggressive, rapidly destructive tumor associated with a delayed diagnosis and a poor outcome. The most common presenting signs and symptoms include hematuria, abdominal or flank pain, and weight loss...

This case report describes the findings of a 18 year-old black male from Bahia, a Northeastern state in Brazil, with the sickle cell trait, who developed bilateral hyphema and vitreous hemorrhage with blindness in the course of leptospirosis. The patient started to complain of blurred vision four days after the start of fever and muscular pain and approximately twelve hours after the introducti...

The medical history should be a communication between the patient and the dentist. A good history will reveal a patient's medical problems,concerns, ideas, and expectations. Understanding medical conditions on a patient's medical history is of up most importance in providing the patient with the best possible standard of care. Sickle cell disease is an inherited blood disorder that affects red ...