Soluble ICAM-1 (sICAM-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction, diabetes, stroke, and malaria. Despite evidence for a heritable component to sICAM-1 levels, few genetic loci have been identified so far. To comprehensively address this issue, we performed a genome-wide association analysis of sICAM-1 concentra...

It is well known that subjects with type 1 diabetes are at an increased risk of death from coronary heart disease in comparison to non-diabetic age-matched individuals because hyperglycaemia is believed to be a key risk factor for the development of micro- and macrovascular complications. On the other hand there is increasing evidence about the role of inflammatory mediators in the pathogenesis...

OBJECTIVE To determine the serum levels of soluble adhesion molecules in patients with juvenile idiopathic arthritis (JIA), and to determine whether the levels of these molecules differ between active disease and remission in the same JIA subtype, and whether differences in these levels exist between controls and the three JIA subtypes. METHODS The serum levels of soluble E-selectin (sE-selec...

Introduction Interleukin-6 (IL-6) orchestrates formation of an inflammatory pannus, leading to joint damage in rheumatoid arthritis (RA). Sarilumab is a human monoclonal antibody blocking the IL-6Rα. In TARGET (NCT01709578), a phase 3 study in adults with moderate-to-severe RA and inadequate response or intolerance to tumour necrosis factor inhibitors, subcutaneous sarilumab 200 mg or 150 mg ev...

We report five children with atopic eczema. The level of soluble adhesion molecules is known to correlate with disease severity. On the assumption that atopic eczema is a T-lymphocyte-mediated inflammatory disease, in this study, we aimed to determine the presence of soluble intracellular adhesion molecule (sICAM) 1 and the release of inflammatory cytokines. The patient sera were used to measur...

Correspondence to: Prof. Brunello Wüthrich, Allergy Unit, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31 CH–8091 Zurich (Switzerland) Dear Sir, We read with interest the letter by Yamada et al. [1]. Our experience is in contrast with the results of the Japanese colleagues. In fact, we have published in the January 1994 issue of Allergy [2] that the measurement of solubl...