To evaluate ceftriaxone for the treatment of shigellosis, 94 adult males with acute dysentery were randomly assigned to receive ceftriaxone (1 g), ampicillin (4 g), or saline placebo intravenously in single doses in a double-blind design. Stool cultures were positive for Shigella dysenteriae in 52 patients, S. flexneri in 38 patients, and other species in 4 patients. Both ceftriaxone and ampici...

Plasmid profiles and antimicrobial susceptibility patterns of 343 strains of Shigella dysenteriae type 1, obtained from 18 different geographical locations, were analyzed. Three plasmids, with molecular sizes of 140, 6, and 2 megadaltons (MDa), were present in 94, 98, and 96%, respectively, of the 343 strains isolated during either epidemic or nonepidemic periods from 1965 to 1987. In addition ...

This work describes the characterization and genome annotation of newly isolated lytic phage vB_SsoM_Z31 (referred to as Z31), from wastewater samples collected in Dalian, China. Transmission electron microscopy revealed that Z31 belongs family Myoviridae, order Caudovirales. specifically infects Shigella sonnei, dysenteriae, Escherichia coli. The is an 89,355-bp-long dsDNA molecule with a G+C ...

Four bacterial strains are described that possess the biochemical characteristics of Shigella species but do not belong to any of the established Shigella serovars or to any previously described provisional serovar. One strain fermented mannitol, and it is proposed that this be the type strain for a new provisional serovar of Shigella boydii. The remaining strains did not ferment mannitol and b...

Shigellosis is an acute diarrheal disease caused by bacteria of the genus Shigella. Following the occurrence of a large outbreak of shigellosis as well as sporadic cases since 1998, shigellosis has been a major health problem in Korea. There have been major changes in epidemiology during the last five decades concerning shigellosis in terms of total incidence of shigellosis, prevalence of certa...

Shigella species and enteroinvasive Escherichia coli (EIEC) belong to the same species genetically, with remarkable phenotypic and genomic similarities. Shigella is the main cause of bacillary dysentery with around 160 million annual cases, while EIEC generally induces a milder disease compared to Shigella. This study aimed to determine virulence variations between Shigella and EIEC using the n...