Methanolic extract of Luffa cylindrica (L.) M. J. Roem. leaves (MELC) was evaluated for its hepatoprotective potential against paracetamol intoxicated wistar rats. Administration of MELC and standard drug silymarin showed significant (P <0.05) hepatoprotective protection in experimental animals. The study was conducted by estimating serum enzyme activities of serum glutamate oxaloacatate transa...

It is difficult to make a retrospective diagnosis of perinatal asphyxia in symptomatic neonates delivered non-institutionally. We studied serum creatine kinase muscle-brain fraction (CK-MB), lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (SGOT) and glutamic pyruvate transaminase (SGPT) for differentiating asphyxiated (n=25) from non-asphyxiated (n=20) neonates who present with n...

Male guinea pigs were maintained on a vitamin C-deficient chow diet and supplemented with either 0.05 or 2.0 mg of ascorbic acid/ml drinking water for 3 weeks prior to receiving an intraperitoneal injection of 4.0 g of ethanol/kg body weight. The following biochemical parameters were measured prior to, and hourly for 12 hours after, ethanol administration: serum glutamic-oxaloacetic transaminas...

background most therapeutic interventions in acute phase of viral hepatitis b patients are conservative. prostaglandins have absorbed many scientists' attention for improving these patients condition, therefore, the present study was designed to evaluate misoprostol (pge1 analogue) effect on acute phase of viral hepatitis b. materials and methods a randomized matched controlled clinical trial w...

Objective(s):The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. Materials and Methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D.  aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) f...

Background and objectives: Coronavirus disease 2019 (COVID-19) is affecting millions of people world-wide. It caused by the severe acute respiratory syndrome corona virus 2(SARS-CoV-2). The laboratory findings are very important to assess progress disease. present study aimed discuss biochemical parameters among mild, moderate COVID-19 patients. Materials methods: A cross sectional were conduct...

liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plants. Feijoa sellowiana (Myrtaceae) is an evergreen bush native to southern areas of South America, as well as Iran where the fruits are very popular. Feijoa has shown a potent antimicrobial effect. Morever, the antioxidant activity of total Feijoa extract has also been reported. MDMA or ecstasy is a ...

The paper aimed to study the toxic effects of the degradation products of oxytetracycline and chlortetracycline, such as, α-apo-oxytetracycline (α-apo-OTC), β-apo-oxytetracycline (β-apo-OTC), anhydro-chlortetracycline (ACTC) and 4epi-anhydro-chlortetracycline (EACTC) on rats. Male rats received oral doses of 10 mg/kg body weight/day of either α-apo-OTC, β-apo-OTC, ACTC or EACTC for 90 d. At the...

AIM To determine the incidence and factors associated with drug induced hepatic dysfunction in children on anti-tuberculous treatment (ATT). SETTING Pediatric Tuberculosis Clinic at B.J. Wadia Children's Hospital, Mumbai. MATERIAL AND METHODS 46 children with tuberculosis on ATT between April 2007 and February 2008 were included. Serum glutamic pyruvic transaminase (SGPT) level was measured...

The present study describes the beneficial effects of potential probiotic E. coli 16 (pUC8:16gfp) expressing Vitreoscilla hemoglobin (vgb) gene, associated with bacterial respiration under microaerobic condition, on gastrointestinal (GI) colonization and its antioxidant activity on carbon tetrachloride (CCl4) induced toxicity in Charles Foster rats. In vitro, catalase activity in E. coli 16 (pU...