The article describes clinical, including neurological manifestations, of giant cell arteritis (GCA) - granulomatous vasculitis of large and medium-sized vessels, predominantly craniofacial, including precerebral and cerebral, arteries. Histopathological features of GCA are illustrated by the schemes of panarteritis and «postarteritis» (proliferative and fibrotic changes in the intima, underlyi...

Giant cell arteritis (temporal arteritis; GCA) is a systemic vasculitis of medium and large arteries, affecting predominantly the aortic branches to the head and neck. Temporal arteritis was first described by Horton et al in 1932 and classically presents with a combination of polymyalgia rheumatica, headache, and manifestations of systemic illness (fever, anemia, anorexia, malaise, and weight ...

similar to a collection of flowers (Fig.2). They were marked by intense glucagon immunostaining. The findingswere consistentwith the recently recognized entity GCA. Mutation analysis of the tissue samples for MEN1, VHL, and p27 genes was unsuccessful because of the poor preservation of DNA within the pancreatic tissue. GCA and GCA-like entities have rarely been reported. In GCA there is no soli...

OBJECTIVE Fetuses conceived by assisted reproductive technology (ART) and those that are small-for-gestational age (SGA) show cardiovascular remodeling in utero; however, these two conditions are often associated. We aimed to evaluate the differential effect of ART and SGA on fetal cardiac remodeling. METHODS This was a prospective cohort study of term singleton pregnancies seen at our depart...

OBJECTIVES To evaluate the risk of aortic aneurysm in patients with giant cell arteritis (GCA) compared with age-, gender- and location-matched controls. METHODS A UK General Practice Research Database (GPRD) parallel cohort study of 6999 patients with GCA and 41 994 controls, matched on location, age and gender, was carried out. A competing risk model using aortic aneurysm as the primary out...

Dysmenorrhoea, pain during menstruation, affects 40-95 per cent of menstruating women, and has been reported as the most common of all gynecologic complaints and the leading cause of absenteeism of women from work, school, and other activities. Common treatment for dysmenorrhoea is medical therapy such as nonsteroidal anti-inflammatories (NSAIDs) or oral contraceptive pills (OCPs) which both wo...

MMP-12, a novel matrix metalloproteinase associated with giant cell arteritis SIR, Identification of specific mediators of arterial damage in GCA is crucial to understand its pathogenesis, and may have important clinical implications both for diagnosis and treatment. Thirty-two non-consecutive patients who underwent a temporal artery biopsy for evaluation of GCA were included in this study. Nin...