نتایج جستجو برای: severe asthma

تعداد نتایج: 386339  

Journal: :The European respiratory journal 2010
P Bhavsar N Khorasani M Hew M Johnson K F Chung

Patients with severe asthma respond less well to corticosteroids than those with non-severe asthma. Increased p38 mitogen-activated protein kinase (MAPK) activation in alveolar macrophages (AMs) from severe asthma patients has been associated with a reduced inhibition of cytokine release by dexamethasone. We determined whether p38 MAPK inhibitors would modulate corticosteroid suppression of cyt...

2017
Akul Singhania Hitasha Rupani Nivenka Jayasekera Simon Lumb Paul Hales Neil Gozzard Donna E. Davies Christopher H. Woelk Peter H. Howarth

Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, with very few utilizing transcriptomic approaches. The small peripheral airways, which comprise the majority of the airway surface area, remain an un...

Journal: :Biological Research For Nursing 2014

Journal: :World Allergy Organization Journal 2016

Journal: :Multidisciplinary Respiratory Medicine 2015

Journal: :Journal of Allergy and Clinical Immunology 2017

Journal: :World Allergy Organization Journal 2016

Journal: :Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2007
Ana Carla Sousa de Araujo Erica Ferraz Marcos de Carvalho Borges João Terra Filho Elcio Oliveira Vianna

OBJECTIVE To determine the prevalence of factors associated with difficult-to-control asthma. METHODS Patients with severe asthma were selected from the outpatient asthma clinic of the Ribeirão Preto School of Medicine Hospital das Clínicas. The patients were divided into two groups: controlled severe asthma and difficult-to-control severe asthma. After new attempts to optimize the severe ast...

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