The thymus gland, where T lymphocyte development occurs, is targeted in malnutrition secondary to protein energy deficiency. There is a severe thymic atrophy, resulting from massive thymocyte apoptosis (particularly affecting the immature CD4+CD8+ cell subset) and decrease in cell proliferation. The thymic microenvironment (the non-lymphoid compartment that drives intrathymic T-cell development...

though intravenous (iv) magnesium sulphate (mgs04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. the aim of this investigation was to evaluate the role of iv mgso4 when used as an adjunct to standard therapy of severe exacerbations of ...

OBJECTIVE To compare the efficacy of locally-prepared ready-to-use therapeutic food (LRUTF) and locally-prepared F100 diet in promoting weight-gain in children with severe acute malnutrition during rehabilitation phase in hospital. STUDY DESIGN Non-randomized Controlled trial. SETTING Pediatric ward of tertiary care public hospital in Central India. STUDY PERIOD 1 October, 2009 to 30th Ma...

OBJECTIVE The objective of our study was to assess the impact of adopting the World Health Organization growth standards and weight-for-height z-score criterion on the response to treatment of severe acute malnutrition in children compared with the use of the National Center for Health Statistics growth reference. METHODS We used data from children aged 6 to 59 months with acute malnutrition ...

In the 1990s, the number of underweight children in developing countries declined from 177 million to 149 million. The incidence of severe malnutrition also declined but, despite this, severe malnutrition remains an important problem (fig 1). 3 In India, for example, 2.8% of children under 5 are severely wasted. Malnutrition is a contributing factor in nearly 60% of deaths in children for which...

Malnutrition plagues a disproportionately large number of children in India compared with most other countries. National-level data on child malnutrition in India have, however, been scarce. Recognizing this gap, India’s 1992–93 National Family Health Survey (NFHS) collected anthropometric data on the height and weight of children below four years of age. The NFHS is based on a large, nationall...