BACKGROUND The aim of the present study was to determine whether sex differences contribute to the association of serum uric acid and left ventricular hypertrophy in individuals with hypertension. METHODS AND RESULTS Seventy participants with essential hypertension (34 men, 36 women; 54.4 +/- 1.6 years old) were enrolled to undergo echocardiography to calculate the left ventricular mass index...

BACKGROUND Elevated serum uric acid has been associated with cognitive dysfunction and vascular cognitive impairment in the elderly. Serum uric acid is also commonly elevated in chronic kidney disease (CKD), but its relationship with cognitive function in these patients has not been addressed. METHODS Subjects with CKD (defined as eGFR <60/ml/min/1.73 m(2)) were evaluated for cognitive dysfun...

Uric acid concentration in serum and urine of 296 persons of Bahawalpur city is reported. Although the general pattern corresponds to the studies in other regions of the world but the range of uric acid concentration in male and female serum and uric acid is slightly higher. Correspondingly the incidence of uricemia is also high in the region with some cases of gout. Statistically, the serum ur...

Patients with type 2 diabetes mellitus (DM) may experience chronic microvascular complications such as diabetic retinopathy (DR) and diabetic nephropathy (DN) during their lifetime. In clinical studies, serum uric acid concentration has been found to be associated with DR and DN. The goal of this study was to evaluate the relationship between the increases in serum uric acid level and the sever...

OBJECTIVES To compare the efficacy and safety of febuxostat and allopurinol in pyrazinamide (PZA)-induced hyperuricemia in patients taking antitubercular therapy (ATT). METHODS This randomized controlled study was conducted at a tertiary care teaching institute of Rajasthan in all the sputum-positive tubercular patients aged between 18 and 65 years of either sex. Serum uric acid level was mon...

The role of serum uric acid as an independent risk factor for cardiovascular and renal morbidity is controversial. A better understanding of its relationship with preclinical organ damage may help clarify the mechanism(s) implicated in the development of early cardiovascular disease. We evaluated the association between uric acid and the presence and degree of target organ damage in 425 (265 ma...

Gout is a common rheumatic disease in humans which is characterized by elevation in serum uric acid levels, and deposition of uric acid crystals in the joint. Hyperuricaemia is the primary risk factor for the development of gout and primates have uniquely high levels of serum uric acid due to missense mutations in the uricase gene. Levels of serum uric acid are known to be highly heritable, and...

The recent article describing a positive association between serum uric acid and several inflammatory markers in the InCHIANTI study addresses the issue of whether uric acid is an independent cardiovascular risk factor. Uric acid is an antioxidant and appears to contribute to salutary immune reactions, but the cardiovascular significance of rises in its serum level remains poorly understood. I ...

Serum uric acid estimations were performed in 106 healthy pregnant women during early, middle, and late pregnancy, using an automated colorimetric method. The mean serum uric acid level was significantly lower during early and middle pregnancy than that of 64 age-matched female controls. The serum uric acid level was not significantly different in late pregnancy from the control group. Studies ...

serum uric acid , trigly c eride and c holestero l l e vel s were measured in 851 healthy adults in tehe ran , i r a n . careful l aboratory and clinical e v a l ua t ion wa s undertaken to exclude any medical problems. onl y 65% were on iddeal weigh t .the mean uric a c i d v a l ues were 6.1 f or male s and 5 . 1 f or f emale s under 30 years of age. uric acid l ev e ls above 6mg in females a...