the precise pharmacological of chronic use of opium on serum level of gonadotropins and male sex hormones are not studied extensively.this study was performed to investigate the changes in these parameters is opium addicted men.the blood samples of 46 opium addicts and 39 normal men were taken ,and the testosterone ,LH and FSH levels in serum were measured by radioimmunoassay (RID) technique us...

Males are more prone to Visceral Leishmaniasis (VL) as compared to females. The role of androgens in host defence against Leishmania and other pathogens is of considerable interest. This study was aimed to understand a baseline mechanistic understanding of the pathogenesis of visceral leishmaniasis with respect to testosterone. We examined the relationship between serum testosterone and cholest...

UNLABELLED Sertoli cell (SC) number determines testes size and their capacity to produce spermatozoa. In the rat SC proliferate until 15th postnatal day (PND). Their proliferation is stimulated by FSH and inhibited by estradiol, but the role for androgens is uncertain. In this study we analyzed the effects of testosterone administration on testes growth and SC number in relation to timing of th...

BACKGROUND In this study, we tested the hypothesis that 17beta-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported increase in serum testosterone after long-term (6 weeks) castration constituted a basis for testing the hypothesis that a spontaneous increase in serum testosterone or androstenedi...

Background: Spermatogenesis is the major factor of male fertility which is pendent on hormones specially testostrone. Testostrone signalling leads to activation of some kinases which are required for progression and maintaining of spermatogenesis. On the other hand, oxidative stress, as the most prevalent factor, influences on fertility. Also, it was shown that chronic oxidative stress in rat t...

background: heroin as opium is being used in two pure and impure forms with known disastrous effects on different body organs including genital system. the aim of this study was to determine the changes in testosterone secretion, the percentage of fertility, changes of the body and testis weight, and gonado somatic index in mice (ballb/c). materials and methods: a total of 90 adult male and fem...

objective(s): present study was performed in order to uncover new aspects for nicotine-induced damages on spermatogenesis cell lineage. materials and methods: for this purpose, 36 mature male wistar rats were divided into three groups as; control-sham (0.2 ml, saline normal, ip), low dose (0.2 mg/kg bw-1, ip) nicotine-received and high dose (0.4 mg/kg bw-1, ip) nicotine-received groups. followi...

INTRODUCTION Androgen decline in the aging man has become a topic of increasing clinical relevance worldwide, as the reduction in testosterone levels has been reported to be accompanied by loss of muscle mass, accumulation of central adiposity, impaired mobility and increase risk of bone fractures. Although well-established in studies conducted in developed countries, progressive decline in ser...

BACKGROUND Analog-based free testosterone test results, sex hormone binding globulin (SHBG) concentrations, and total testosterone concentrations are somehow related. This study used new experiments to clarify these relationships. METHODS An analog-based free testosterone immunoassay and a total testosterone immunoassay were applied to well-defined fractions of serum testosterone. First, they...

background: diabetes mellitus has a variety of structural and functional effects on the male reproductive system. diabetes results in reduced sperm parameters and libido. the present study aims to investigate the effects of royal jelly (rj) on reproductive parameters of testosterone and malondialdehyde (mda) production in diabetic rats. materials and methods: this experimental study was conduct...