BACKGROUND Resistance to EPO therapy in hemodialysis (HD) patients is ascribed to inflammation and iron deficiency. Hepcidin, an antimicrobial peptide, is a key regulator of iron metabolism and synthesis of hepcidin is regulated by iron status and inflammation. The role of hepcidin in the pathogenesis of EPO-resistant anemia was assessed through measurement of serum pro-hepcidin in HD patients....

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors. Its incidence is rated as one among the highest in the world and the use of tobacco in various forms is increasingly associated with the cause of OSCC. Levels of serum copper and iron was estimated and compared among subjects with tobacco habits and healthy controls. OSCC patients were categorized according the toba...

A 38-day-old male warthog (Phacochoerus aethiopicus) with marked anaemia (haematocrit = 14 %) presented to the Denver Zoological Gardens hospital with ataxia, tachypnoea, suspected stunted growth and cardiomegaly. The piglet demonstrated some features consistent with both iron deficiency anaemia and autoimmune haemolytic anaemia. Serum-soluble iron was below the level of detection (< 8.96 micro...

Serum ferritin rises in the anemia of chronic inflammation reflecting increased iron storage and other changes mediated by inflammation. When iron deficiency coexists, the ferritin may not always decline into the subnormal range. We describe the rare interaction of iron deficiency with the extreme hyperferritinemia characteristic of adult onset Still's disease. The combination has clinical rele...

Because of the large quantities of venous blood required, assays of total iron-binding capacity (TIBC) and serum iron are often omitted in diagnostic tests involving small children. As an alternative to the conventional method of assessing TIBC, we developed a micromethod based on flameless atomic absorption spectrophotometry (flameless AAS). Additionally, the standard microproc#{233}dure for d...

dependent on iron delivery to developing erythrocytes; increased transferrin saturation may be essential to deliver iron when DMT1 activity is diminished. Thus, even if medications that increase hepcidin levels become available for treatment of iron overload, they may not benefit DMT1 patients because increased plasma hepcidin level would limit release of iron into the bloodstream, decreasing s...

Background. Studies have reported that obesity has an adverse effect on iron metabolism. Obesity is characterized by chronic, low-grade, systemic inflammation and anemia of chronic disease with elevated serum ferritin and decreased level of serum iron, transferrin saturation, and hemoglobin. Therefore, we examined the association of body mass index with hemoglobin concentration and iron paramet...

OBJECTIVES Aminoglycosides are highly effective against bacteria but have serious side-effects including ototoxicity and nephrotoxicity. One of the theories in aminoglycosides ototoxicity is that Iron-aminoglycoside complex causes ototoxicity by creating free radicals. Based on this theory, the relationship between serum iron level and amikacin ototoxicity was studied to determine whether more ...

background: a hypothesis has been presented about the role of serum iron, ferritin and transferrin saturation among patients with non-alcoholic fatty liver disease (nafld) and resistance to insulin (metabolic syndrome [mets]), but there is much controversy. this study aimed at investigating the level of serum iron and demographic characteristics in patients with nafld with or without mets. meth...