conventional assays of serum creatinine in the future and the MDRD formula has recently been re-calibrated to IDMStraceable serum creatinine values [4]. Until there is widespread adoption of IDMS creatinine analysis, we believe the four-variable MDRD formula represents an improvement compared with serum creatinine alone for detection of chronic kidney disease. As with any first order screening ...

UNLABELLED Cystatin C, a cysteine protease inhibitor, has been recommended as a new marker of glomerular filtration rate (GFR). THE AIM OF STUDY We investigated significance of cystatin C in assessment of GFR and its influence on overall survival (OS) in patients with ovarian cancer (OC). MATERIAL AND METHODS We prospectively included consecutive patients with OC, who after surgery were quali...

BACKGROUND After open-heart surgery, a percentage of patients have impaired renal function. This deterioration is even seen in patients with serum creatinine (s-creatinine) values that fall within the normal laboratory range, therefore s-creatinine is not an accurate reflection of renal function. Glomerular filtration rate (GFR) is a better indication of renal status. GFR can be calculated with...

Reduction in glomerular filtration rate (GFR) is a common complication in advanced stages of heart failure (HF). The convenient and precise assessment for GFR would be useful for early detection of renal impairment in HF dogs. Our hypothesis of this study was the GFR would be reduced in advanced stages of HF from chronic mitral valvular insufficiency (CMVI), as indicated by renal markers includ...

BACKGROUND The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is most accurate for estimating glomerular filtration rate (GFR) but requires an adjustment for African-American patients. Estimation equations are also improved with the use of serum cystatin C combined with standardized creatinine. Combination equations have been derived by the CKD-EPI and Chinese investigator...

OBJECTIVE The aim of this study was to compare cystatin C versus creatinine as a marker for acute kidney injury in patients submitted to cardiac surgery with cardiopulmonary bypass. METHODS Fifty consecutive patients submitted to coronary artery bypass grafting were studied. Renal function was evaluated by serum cystatin C and creatinine. Blood samples were obtained from each patient at three...

The best overall index of renal function is the glomerular filtration rate (GFR) [1]. Since measuring the GFR can be cumbersome and costly, estimation of GFR is essential for the diagnosis and evaluation of chronic kidney disease (CKD), defined as kidney damage or GFR <60 niL/min/1.73 m 2 for ≥3 months and staged by levels of GFR according to the NKF KDOQI (The National Kidney Foundation Kidney...

BACKGROUND Early identification of impairment in renal function is crucial in diabetic patients. Serum cystatin C may be the most sensitive indicator of glomerular filtration rate (GFR) in the clinical setting. METHODS We compared cystatin C with creatinine, the Cockcroft-Gault (C-G) formula, and the Modification of Diet in Renal Disease (MDRD) study equation for the assessment of early decre...

BACKGROUND Acute kidney injury (AKI) is common after severe paraquat poisoning and usually heralds a fatal outcome. The rapid large increases in serum creatinine (Cr) exceed that which can be explained by creatinine kinetics based on loss of glomerular filtration rate (GFR). METHODS AND FINDINGS This prospective multi-centre study compared the kinetics of two surrogate markers of GFR, serum c...