Introduction: Vincristine (VCR) is potential anti-cancer drug that is highly toxic for renal tissue. This study aimed to evaluate the protective effect of alcoholic extract of saffron stigma against vincristine renal toxicity in male rats. Methods: A total number of 50 rats were randomly divided into 10 groups. Different doses of VCR (0.25, 0.5 and 0.75mg/kg) and saffron (0.5 and ...

background: the purpose of our study was to determine the effect of n-acetylcysteine (nac) administered after successful cardiopulmonary resuscitation (cpr) on renal function of the survived patients. methods: in this double-blinded randomized clinical trial, 44 patients who experienced cardiopulmonary arrest and underwent successful cardiopulmonary resuscitation (cpr) were entered into the stu...

Six patients, aged from 16 to 56 with various types of glomerulonephritis and deteriorating renal function underwent a total of four to six 2!-litre plasma exchanges using the Haemonectics-30 intermittent flow separator at 4-7 day intervals. The replacement fluid consisted of 2 litres of either plasma protein fraction or polygeline with 500 ml of normal saline containing 5000 units of heparin a...

The nephrotoxic potentials of the new aminoglycoside SCH 21420 and amikacin were compared in a rat model. Groups of rats received 100, 200, 300, or 600 mg of either drug per kg per day for 14 days. Enzymuria, urine osmolality, protein excretion, and blood urea nitrogen were monitored at periodic intervals, whereas creatinine clearance and pathological changes were determined at sacrifice. Amika...

BACKGROUND The presence of hyperuricemia and renal function impairment, especially in the absence of urate stone formation is strongly suggestive of lead nephropathy. The evaluation of this association is essential in areas where lead exposure is still prevalent and uncontrolled. OBJECTIVE To determine the relationship between serum uric acid and renal function indices in lead-exposed workers...

background nephrotoxicity and hepatotoxicity are side effects of cisplatin (cp) therapy. objectives we investigated the role of gender in cp-induced nephrotoxicity and hepatotoxicity. materials and methods low dose of cp (1 mg/kg/day; ip) was administered daily to male and female wistar rats for 15 consecutive days. serum creatinine (cr), blood urea nitrogen (bun), malondialdehyde (mda), nitric...

PURPOSE Acute kidney injury (AKI) in major burn patients is a common complication with high morbidity and mortality. The mainstream treatment is early diagnosis and rapid termination and prevention of the underlying insult. Therefore, it's essential to identify early biomarkers predicting AKI. METHODS A total of 85 patients who were admitted to the burn intensive care unit from June 2012 to J...