Although L-serine proceeds in just three steps from the glycolytic intermediate 3-phosphoglycerate, and as much as 8% of the carbon assimilated from glucose is directed via L-serine formation, previous attempts to obtain a strain producing L-serine from glucose have not been successful. We functionally identified the genes serC and serB from Corynebacterium glutamicum, coding for phosphoserine ...

D-Serine and glycine are coagonists of NMDA receptors (NMDARs), but their relative contributions for several NMDAR-dependent processes are unclear. We now report that the alanine-serine-cysteine transporter-1 (Asc-1) mediates release of both D-serine and glycine from neurons, and, in turn, this modulates NMDAR synaptic activity. Asc-1 antiporter activity is enhanced by D-isoleucine (D-Ile), whi...

The plasmalemma of thallus cells of the aquatic liverwort, Riccia fluitans, is reversibly depolarized by L- and D-serine. At 0.1 mM K+ in the medium, the depolarization saturates at 50 mV; half-maximal depolarization occurs at 13 microM L-serine and 30 microM D-serine, respectively. Uptake of 14C-labelled L-serine depends upon the K+ concentration and is sensitive to the membrane potential as i...

Considerable evidence has now been accumulated for the interconversion of glycine and serine in the aniimal body and in micro-organisms. Following the discovery by Shemin (1946) ofthe conversion of isotopically labelled serine into glycine in rats and guinea pigs, the reverse process, that is, the biosynthesis of serine from labelled glycine was also found to occur in the intact animal (Sakami,...

d-Serine is abundant in the forebrain and physiologically important for modulating excitatory glutamatergic neurotransmission as a coagonist of synaptic N-methyl-d-aspartate (NMDA) receptor. NMDA signaling has been implicated in the control of food intake. However, the role of d-serine on appetite regulation is unknown. To clarify the effects of d-serine on appetite, we investigated the effect ...

The native l-serine deaminase (l-serine hydrolyase, deaminating, EC 4.2.1.13) of Escherichia coli K-12, which seems to be a very labile protein, is rather stable in concentrated solution. Dilution rapidly inactivates it, but in the presence of a saturating concentration of l-serine the molecule is protected from inactivation. It is a very specific enzyme; l-serine is the sole substrate with a K...

BACKGROUND Hyperhomocysteinemia plays an important role in the development of hepatic steatosis, and studies indicate that homocysteine-lowering treatment inhibits the development of fatty liver. OBJECTIVE We evaluated the effects of L-serine on alcoholic fatty liver and homocysteine metabolism. METHODS In a binge ethanol study, male C57BL/6 mice were divided into 4 groups: control, ethanol...

TO THE EDITOR Accumulating evidence suggests that patients with schizophrenia exhibit nonpsychotic, nonspecific prodromal symptoms for several years before the onset of frank psychosis. A meta-analysis demonstrated that cognitive impairment is a common feature of the prodromal state of psychosis. Accordingly, interest in the potential benefit of early intervention in psychosis is increasing. We...

Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that caused activation of the classic complement pathway. Sutimlimab, humanized monoclonal antibody, selectively targets C1s protein, C1 complex serine protease responsible for activating this

Amyloid β peptide (Aβ) is the major pathogenic molecule in Alzheimer's disease (AD). BACE1 enzyme essential for generation of Aβ. Deficiency p38α-MAPK neurons increases lysosomal degradation and decreases Aβ deposition brain APP-transgenic mice. However, mechanisms mediating effects are largely unknown. In this study, we used mice cultured observed that deletion specifically decreased phosphory...