conclusions: hydroxyurea can be safely used in some transfusion-dependent β-thalassemia patients to decrease their transfusion needs. background: β-thalassemia is an inherited hemoglobin disorder caused by defective synthesis of ß-globin chains. hemoglobin (hb) f induction is a possible therapeutic approach which can partially compensate for α and non-α globin chains imbalance. objectives: we a...

sepsis and septic shock are among mortality causes following major surgeries. the charlson co-morbidity index consists of 19 weighted categories related to chronic health which measures the burden of co-morbidity. the goal of this study was to determine the incidence of postoperative sepsis in patients underwent gynecological and gastrointestinal cancer surgeries and predictive role of charlson...

1 U.O. Centro Trasfusionale e di Immunoematologia, Dip. di Medicina Rigenerativa, Fond. Osp. Maggiore Policlinico, Mangiagalli e Regina Elena, Ist. di Ricovero e Cura a Carattere Scientifico, Milan, Italy 2 Education Services, Immucor Inc., Norcross, GA, USA 3 U.O. Medicina Interna II, Fond. Osp. Maggiore Policlinico, Mangiagalli e Regina Elena, Ist. di Ricovero e Cura a Carattere Scientifico, ...

Delayed hemolytic transfusion reactions continue to occur in spite of the use of all of the currently available techniques of antibody detection. Both low titers of the antibodies and dosage effects appear to contribute to the failure of detection. A rapid anamnestic response can occur with transfusion of the appropriate antigen. The clinical as well as the laboratory presentation of delayed he...

Transfusion-related acute lung injury (TRALI) is a noncardiogenic pulmonary edema that occurs during or within 6 hours after transfusion. Risk factors for TRALI, which is relatively common in critically ill patients, include recent surgery, hematologic malignancy, and sepsis. Here, we report a case of TRALI induced by anti-human leukocyte antigen (anti-HLA) class II antibodies (HLA-DR) occurrin...

Babesiosis has only recently been reported in Canada, but a number of transfusion-transmitted cases of this infection have been reported from the United States. We present a case of transfusion-transmitted babesiosis that occurred in Canada. Canadian physicians must consider babesiosis in the differential diagnosis of patients who experience fever or a hemolytic reaction after blood transfusion...

BACKGROUND Naturally occurring alloantibodies produced against A and B red cell antigens in cats can cause acute hemolytic transfusion reactions. Blood incompatibilities, unrelated to the AB blood group system, have also been suspected after blood transfusions through routine crossmatch testing or as a result of hemolytic transfusion reactions. HYPOTHESIS Incompatible crossmatch results among...