During cardiogenesis the epicardium, covering the surface of the myocardial tube, has been ascribed several functions essential for normal heart development of vertebrates from lampreys to mammals. We investigated a novel function of the epicardium in ventricular development in species with partial and complete septation. These species include reptiles, birds and mammals. Adult turtles, lizards...

A 22-year-old man with end-stage renal disease on haemodialysis (HD) was admitted to our hospital with a generalized abdominal pain. He had been on HD without complications the previous year. One year before admission, peritoneal dialysis was discontinued because of peritonitis due to candida infection. At physical examination, his blood pressure was 150/90mmHg and heart rate was 90 b.p.m. His ...

STUDY QUESTION Does the European Society of Human Reproduction and Embryology-European Society for Gynaecological Endoscopy (ESHRE-ESGE) classification of female genital tract malformations significantly increase the frequency of septate uterus diagnosis relative to the American Society for Reproductive Medicine (ASRM) classification? SUMMARY ANSWER Use of the ESHRE-ESGE classification, compa...

Purpose/results. We evaluated the diagnostic accuracy of magnetic resonance imaging (MRI) for 46 consecutive patients with lipomatous soft tissue tumors prior to biopsy and resection. Twenty-eight patients had benign lipomas and 18 had liposarcomas. Clinical differences between thdse patients with benign disease and those with malignant lesions were average age at the time of presentation (49 y...

BACKGROUND Expression of kisspeptin (protein) and Kiss1r (mRNA) was recently documented in the mouse uterus on D4 of pregnancy (the day of embryo implantation) suggesting that the uterine-based kisspeptin (KP)/kisspeptin receptor (KISS1R) signaling system regulates embryo implantation. Despite this important suggestion, it was never demonstrated that the uterus actually exhibits a functional KP...

BACKGROUND Uterus transplantation is the first available treatment for absolute uterine infertility, which is caused by absence of the uterus or the presence of a non-functional uterus. Eleven human uterus transplantation attempts have been done worldwide but no livebirth has yet been reported. METHODS In 2013, a 35-year-old woman with congenital absence of the uterus (Rokitansky syndrome) un...

Uterus transplantation is today the only available treatment for absolute uterine factor infertility which is caused by either congenital/surgical uterine absence or that a present uterus is non-functioning. Structured animal-based research, from rodents to nonhuman primates, was the scientific basis for a successful introduction of uterus transplantation as a clinical procedure. The patient gr...

Introduction: Uterine torsion is a rare gynecological emergency, defined as of the uterus greater than 45° around its axis. Case reports describe either in gravid or postmenopausal women, yet rarely non-gravid, premenopausal uterus. This report describes case uterine secondary to large pedunculated fibroid 34-year-old nulliparous woman.

BACKGROUND Mast cells (MCs) have long been suspected as important players for implantation based on the fact that their degranulation causes the release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in the attachment and posterior invasion of the embryo into the uterus. Moreover, MC degranulation correlates with angiogenesis during pregnancy. The n...