Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Interestingly, sepsis mortality increases with acute kidney injury (AKI) and patients with AKI worsen with sepsis. It is interesting to note that most of the clinical trials on sepsis treatment that derived from the results of translational researches are a failure. This is, in part, because of the com...

Nobiletin (NOB), a plant-based polymethoxyflavone, is promising protective agent against sepsis; yet the mechanisms were not fully elucidated. Gut microbiota found to be strongly associated with sepsis-associated acute...

We have demonstrated that regulation of Toll-like receptor 4 (TLR4) surface expression levels on blood CD14(+) monocytes by simvastatin treatment in patient with sepsis is different from that in patients with severe sepsis. In patients with sepsis simvastatin treatment statistically significantly decreased TLR4 surface expression level on blood CD14(+) monocytes, while in patients with severe s...

Objective(s): Sepsis can result in severe organ injury by provoking inflammatory cascades and oxidative stress. Several studies are currently underway to find a drug with anti-inflammatory effects to prevent mortality and morbidity during sepsis. The present study was undertaken to assess the effects of metformin on oxidative stress and antioxidant status in sepsis induced by the Cecal Ligation...

Sepsis is associated with dysregulated cortisol secretion, leading to abnormal levels of in the blood. In early stages condition, are typically elevated due increased secretion from adrenal glands. However, as disease progresses, may decline impaired function, relative insufficiency. The latter thought be caused by a combination factors, including decreased production corticotropin-releasing ho...

Aim: Sepsis is a life-threatening organ dysfunction accompanied by dysregulated host response to infection. Patients with sepsis may present different clinical manifestations, and there no gold standard diagnostic test. Early diagnosis rapid treatment result in decrease sepsis-related deaths. Quick Sequential Organ Failure Assessment (qSOFA) scoring system used diagnosing through evaluation at ...

Abstract Background Sepsis is the leading cause of death in hospitalized patients intensive care unit (ICU). Although substantial progress has been made studies on treatment sepsis, mortality rate remains extremely high. We have previously reported that electroacupuncture (EA) induced tolerance against but underlying mechanism unclear. Methods C57BL/6 mice were pretreated with EA before sepsis ...

Background. Long-term outcomes (mortality and health-related quality of life) of sepsis have risen as important indicators for health care. Pulmonary infection and abdominal infection are the leading causes of sepsis. However, few researches about long-term outcomes focused on the origin of sepsis. Here we aim to study the clinical differences between pulmonary-sepsis and abdominal-sepsis and t...