The hearing of 111 perinatal intensive care survivors of birthweights 1500 g or less was assessed at a mean age of 64 years (range 4-12). These 111 infants included 86% of the longterm survivors of this birthweight cared for in the newborn unit of University College Hospital, London, during the years 1966-72. All these infants were nursed in commercially available incubators for periods ranging...

Sensory development is complex, with both morphologic and neural components. Development of the senses begins in early fetal life, initially with structures and then in-utero stimulation initiates perception. After birth, environmental stimulants accelerate each sensory organ to nearly complete maturity several months after birth. Vision and hearing are the best studied senses and the most cruc...

Sensorineural hearing loss (SNHL) is the most common congenital deficit. As non genetic contributions congenital cytomegalovirus infection (cCMV) is the most frequent cause for this disease. In 10% 20% of patients with sensorineural hearing loss intrauterine infection with cytomegalovirus is diagnosed. Hearing impairment due to CMV can be diagnosed at birth; nevertheless 33% 50% is late-onset l...

Aggregation of diabetes and hearing loss in a family is observed in some hereditary disease. All members of the present family are affected with sensory hearing loss and diabetes mellitus. Diabetes types observed were insulin dependent diabetes mellitus (IDDM) in the proposita and the sister, non-insulin dependent diabetes mellitus (NIDDM) in the brother, and impaired glucose tolerance in the m...

CHARGE syndrome is a multiple congenital anomaly disorder that leads to life-threatening birth defects, such as choanal atresia and cardiac malformations as well as multiple sensory impairments, that affect hearing, vision, olfaction and balance. CHARGE is caused by heterozygous mutations in CHD7, which encodes an ATP-dependent chromatin remodeling enzyme. Identification of the mechanisms under...

hearing loss (hl) is the most common sensory defect. various genetic as well as environmental factors have been shown to contribute in it. more than 100 loci have been recognized to cause autosomal recessive nonsyndromic hearing loss (arnshl). here, we report a 6-year old female patient with bilateral pre-lingual hl in whom a mutation has been identified in triobp gene (c.6362c>t, s2121l). in s...

OBJECTIVE To address the characteristics of hearing loss in patients with Turner syndrome (TS), we evaluated hearing levels of patients with TS and analyzed causative factors. STUDY DESIGN Thirty-three patients with TS (8 to 40 years of age) were studied through the use of audiological measurements, and causative factors were explored. RESULTS Twenty cases (35 of 66 ears tested) showed high...

Although concurrent vision and hearing loss are common in older adults, population-based data on their relationship with mortality is limited. This cohort study investigated the association between objectively measured dual sensory impairment (DSI) with mortality risk over 10 years. 2812 Blue Mountains Eye Study participants aged 55 years and older at baseline were included for analyses. Visual...

Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for the protein truncating mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4 (NESP4), an outer nuclear membrane (ONM) protein expressed in the hair cells of the ...

introduction: conductive hearing loss due to chronic otitis media (com) can be treated by surgery. com, however, may be associated with functional damage to the inner ear. sensorineural hearing loss (snhl) due to com has been found to be significant by some authors, whereas it has been considered negligible by others. the present study aimed to answer the question does com cause snhl ? methods:...