2 groups of children with phenylketonuria, those with a history of early sensory restriction or isolation and those without, were compared on measures of (a) interpersonal behavior, (b) language comprehension, (c) intelligence, and (d) incidence and severity of personality disturbances. The findings, discussed in the context of sensory-deprivation and sensory-restriction research, supported the...

Abstract Temporally speaking, the Russian Revolution of 1917 was not a news item, even rumor, but first and foremost novel sensory impression—gunshots with live ammunition from unusual places, smell burnt police files. This article explores history revolution through ego-documents like diaries memoirs. It tracks in detail how people various backgrounds Petrograd Moscow lived olfactory class str...

In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-typ...

Stereotyped motor behavior manifests as rhythmic, repetitive movements. It is common in several neurologic and psychiatric disorders where it is considered maladaptive. However, it also occurs early in typical development where it serves an adaptive function in the development of complex, controlled motor behavior. Currently, no framework accounts for both adaptive and maladaptive forms of moto...

Introduction A representationalist about qualia takes qualitative states to be aspects of the intentional content of sensory or sensory-like representations. When you experience the redness of an apple, they say, your visual system is merely representing that there is a red surface at such-and-such a place in front of you. And when you experience a red afterimage, your visual system is (non-ver...

In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-typ...

During postnatal development, sensory experience modulates cortical development, inducing numerous changes in all of the components of the cortex. Most of the cortical changes thus induced occur during the critical period, when the functional and structural properties of cortical neurons are particularly susceptible to alterations. Although the time course for experience-mediated sensory develo...

Development of the cerebral cortex is influenced by sensory experience during distinct phases of postnatal development known as critical periods. Disruption of experience during a critical period produces neurons that lack specificity for particular stimulus features, such as location in the somatosensory system. Synaptic plasticity is the agent by which sensory experience affects cortical deve...

Development of proper cortical circuits requires an interaction of sensory experience and genetic programs. Little is known of how experience and specific transcription factors interact to determine the development of specific neocortical circuits. Here, we demonstrate that the activity-dependent transcription factor, Myocyte enhancer factor-2C (Mef2c), differentially regulates development of l...

We studied the role of sensory experience in the maturation of GABAergic circuits in the rat visual cortex. Between the time at which the eyes first open and the end of the critical period for experience-dependent plasticity, the total GABAergic input converging into layer II/III pyramidal cells increases threefold. We propose that this increase reflects changes in the number of quanta released...