OBJECTIVES To examine the association between visual and hearing impairment and motor vehicle collision (MVC) involvement in older drivers. DESIGN Retrospective cohort study. SETTING North central Alabama. PARTICIPANTS Population-based sample of 2,000 licensed-drivers aged 70 and older. MEASUREMENTS Visual acuity was measured using the Electronic Visual Acuity test. Contrast sensitivity...

Neuropsychomotor development (DNPM) is a journey of great transformations. It begins at the moment conception and continues throughout life, allowing acquisition functionality independence for increasingly complex elaborate activities in adult individual. Intellectual, physical, socio-emotional language are influenced by biological or genetic factors, such as prematurity, syndromes, perinatal a...

1 A closed-loop approach to sensorimotor behaviors.................................p.9 1.1. Defining sensorimotor behaviors 1.1.1. Eliciting sensory input 1.1.2. Measuring motor output 1.2. Modulating sensorimotor behaviors 1.2.1. Sensory feedback 1.2.2. Neuromodulation 1.3. Modeling sensorimotor behaviors 1.3.1. Behavioral computations 1.3.2. Circuits computations 2 An open-loop access: sensor...

Background/Aim. The prevalence of diabetes mellitus in general population is constantly increasing. On the other hand, number diabetic patients with neuropathic pain large. aim study was to examine influence on quality life (QoL) sensorimotor polyneuropathy (DSPN) who did not have any complication or significant comorbidity. Methods. A total 32 DSPN and definitive were compared without pain. re...

The proto-oncogene pleomorphic adenoma gene 1 (Plag1) encodes a zinc finger transcription factor. PLAG1 is part of the high motility group AT hook-2 (HGMA2)–PLAG1–insulin-like growth factor 2 (IGF2) pathway that, when disrupted, leads to Silver–Russell syndrome, severe form intrauterine restriction. With little known about PLAG1’s role in normal physiology, this study first characterise behavio...

This issue of Biological Psychiatry contains a thoughtprovoking article by Ivleva et al. (1) reporting on data generated as part of the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) project. The B-SNIP project is an important effort that was started to help identify the similarities and differences across individuals with a spectrum of psychotic disorders, including schizop...

Although second-generation antihistamines generally penetrate the blood-brain barrier to a lesser degree than the powerfully impairing firstgeneration antihistamines, many have been found to produce dose-related impairment of central nervous system (CNS) function. In contrast, fexofenadine has been determined to be truly nonimpairing, even at supraclinical doses. Crossover studies using placebo...

BACKGROUND Stress is a significant factor in the etiology of depression. Stellate ganglion block (SGB) has been shown to maintain the stability of the autonomic system and to affect the neuroendocrine system, including the hypothalamic-pituitary-adrenal (HPA) axis. The objective of this study was to determine the antidepressant-like effects of SGB on the autonomic system and the HPA axis, apopt...