Senescence is a stable proliferation arrest, associated with an altered secretory pathway, thought to promote tumor suppression and tissue aging. While chromatin regulation and lamin B1 down-regulation have been implicated as senescence effectors, functional interactions between them are poorly understood. We compared genome-wide Lys4 trimethylation on histone H3 (H3K4me3) and H3K27me3 distribu...

Tobacco smoke-induced accelerated cell senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cell senescence is accompanied by the accumulation of damaged cellular components suggesting that in COPD, inhibition of autophagy may contribute to cell senescence. Here we look at whether autophagy contributes to cigarette smoke extract (CSE) - induced cel...

Cellular senescence results in proliferation arrest and acquisition of hallmarks such as the Senescence-Associated Secretory Phenotype (SASP). Senescence is involved in regulating numerous physio-pathological responses, including embryonic development, cancer, and several aging-related diseases. Only a few kinases, centered on the RAS signaling pathway, have been identified as inducing prematur...

Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key mechanism driving replicative senescence in human fibroblasts. Later, pioneering work by Olivier Toussaint and others showed that stress plays a major role in the induction of senescence in vitro, a phenomenon known as ...

Cellular senescence is a stable proliferation arrest associated with an altered secretory pathway (senescence-associated secretory phenotype). Cellular senescence is also a tumor suppressor mechanism, to which both proliferation arrest and senescence-associated secretory phenotype are thought to contribute. The melanocytes within benign human nevi are a paradigm for tumor-suppressive senescent ...

Senescence occurs at every stage of plant development. Shriveling of the cotyledons in young plants and the seasonal recurrence of leaf yellowing are obvious examples. Similarly, after pollination, petals have fulfilled their biological role and become senescent. Despite this ubiquity, however, the molecular events that initiate senescence have thus far remained a mystery. Thimann et al. (1977)...

the effect of different storage temperatures on senescence and postharvest performance in cut scapes of three iris species (iris germanica, iris reticulata and iris kashmiriana) was studied with the aim to develop a cost-effective storage protocol so as to bring out the transportation of these cut flowers. the scapes were subjected to two different storage treatments-dry storage and wet storage...

Senescence occurs at every stage of plant development. Shriveling of the cotyledons in young plants and the seasonal recurrence of leaf yellowing are obvious examples. Similarly, after pollination, petals have fulfilled their biological role and become senescent. Despite this ubiquity, however, the molecular events that initiate senescence have thus far remained a mystery. Thimann et al. (1977)...

Senescence is a well-known cellular event characterized by specific markers like permanent cell proliferation arrest and the secretion of messenger molecules forming Senescence-Associated Secretory Phenotype (SASP). The SASP composition depends on many factors such as type nature stress that induced senescence. Since skin constitutes barrier with external environment, it particularly subjected ...

Hyperglycemia was reported to cause bone marrow hematopoietic niche dysfunction, and high glucose (HG) in the cultured medium induces MSC senescence. The underlying mechanism is unclear. Here, we investigated the role of HG-induced autophagy in bone-marrow-derived mesenchymal stem cell (BMSC) senescence. HG (25 mM) increased expression of Beclin-1, Atg 5, 7 and 12, generation of LC3-II and auto...