نتایج جستجو برای: seminiferous tubules
تعداد نتایج: 14448 فیلتر نتایج به سال:
BACKGROUND Tacrolimus (FK-506) is an immunosuppressant that binds to a specific immunophilin, resulting in the suppression of the cellular immune response during transplant rejection. Except for some alterations in the spermatozoa, testicular morphological alterations have not been described in rats treated with tacrolimus. In the present study, we purpose to evaluate if the treatment with tacr...
Seminiferous tubular atrophy may involve indirectly the disruption of estrogen receptor-α (ESR1) function in efferent ductules of the testis. ESR1 helps to maintain fluid resorption by the ductal epithelium and the inhibition or stimulation of this activity in rodent species will lead to fluid accumulation in the lumen. If not resolved, the abnormal buildup of fluid in the head of the epididymi...
BACKGROUND AND AIMS In mammalian spermatogenesis, glial cell line-derived neurotrophic factor (GDNF) is one of the major Sertoli cell-derived factors which regulates the maintenance of undifferentiated spermatogonia including spermatogonial stem cells (SSCs) through GDNF family receptor α1 (GFRα1). It remains unclear as to when, where and how GDNF molecules are produced and exposed to the GFRα1...
Background: Neem leaves (Azadirachta indica L.) have been used for many therapeutic purposes and medicinal applications. The extract of this plant has been used in both male and female genders as a traditional agent to prevent early pregnancy. In this study, the effect of this extract was investigated histologically and morphometrically on the germinal epithelia of the seminiferous tubules, epi...
Background: Varicocele is a dilated vein of the pampiniform plexus that cause to det-rimental time-dependent effects so this study describes the effect of varicocele on the level of IL-6 and interferon gamma in serum and testis tissue, number of sertoli and spermatogonia cells, seminiferous tubules diameter and sperm activity in immature rats. Methods: Thirty six immature rats, 5-6 weeks aged ...
The present study investigates the anti-spermatogenic potential of ethanolic extract of Matricaria recutita a plant belonging to Asteraceae family. The effects of an ethanolic extract of the Matricaria recutita on spermatogenesis, histology of testis and level of testosterone were examined in control and experimental groups. Results showed that Matricaria recutita extract did not cause any chan...
This report describes 2 cases of spontaneous intratubular spermatocytic seminomas in Sprague-Dawley rats. These rats were sacrificed at 10 weeks old (case 1) and 40 weeks old (case 2), respectively. Macroscopically, there were no remarkable changes in either case. Microscopically, tumor cells were observed within a single seminiferous tubule (case 1) or several seminiferous tubules (case 2). Th...
The aim of the study was to estimate morphology in the testis and epididymis of adult rats, treated with finasteride for 28 days (the time period of two seminiferous epithelium cycles) and 56 days (the time period of one spermatogenesis). A 28 days long DHT deficiency did not significantly influence the structure of seminiferous epithelium. After 56 days of treatment, finasteride induced slough...
Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that is down regulated in human seminoma. Depletion of Gravin correlates with an increased mitotic inde...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید