A cortical model for motion-in-depth selectivity of complex cells in the visual cortex is proposed. The model is based on a time extension of the phase-based techniques for disparity estimation. We consider the computation of the total temporal derivative of the time-varying disparity through the combination of the responses of disparity energy units. To take into account the physiological plau...

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

The Ring Model of orientation tuning is a dynamical model of a hypercolumn of visual area V1 in the human neocortex that has been designed to account for the experimentally observed orientation tuning curves by local, i.e., cortico-cortical computations. The tuning curves are stationary, i.e. time independent, solutions of this dynamical model. One important assumption underlying the Ring Model...

The ability to discriminate between self and others movements is an important ability at the basis of our capacity to relate to others socially and to learn by imitation {Billard2002}. Current body of evidence suggests a common neural substrate to the recognition and production of movements in both humans and monkeys {Iacoboni1999, Rizzolatti2001}. A behavioral correlate of such discovery, rela...

In recent years, olefin cross metathesis (CM) has emerged as a powerful and convenient synthetic technique in organic chemistry; however, as a general synthetic method, CM has been limited by the lack of predictability in product selectivity and stereoselectivity. Investigations into olefin cross metathesis with several classes of olefins, including substituted and functionalized styrenes, seco...

To be effective, a designed drug must discriminate successfully the macromolecular target from alternative structures present in the organism. The last few years have witnessed the emergence of different computational tools aimed to the understanding and modeling of this process at molecular level. Although still rudimentary, these methods are shaping a coherent approach to help in the design o...

the possibility of selective leaching process was investigated during molybdenite flue dust leaching to recover its rhenium content. the results show that addition of alcohols to water makes the medium less favorable for molybdenum transfer into aqueous phase. on the other hand, addition of small amounts of alcohols (5-15%) makes a noticeable separation of rhenium over molybdenum, but by increa...

The starburst amacrine cell (SBAC), found in all mammalian retinas, is thought to provide the directional inhibitory input recorded in On-Off direction-selective ganglion cells (DSGCs). While voltage recordings from the somas of SBACs have not shown robust direction selectivity (DS), the dendritic tips of these cells display direction-selective calcium signals, even when gamma-aminobutyric acid...

Despite its sequence variability and structural flexibility, the V3 loop of the HIV-1 envelope glycoprotein gp120 is capable of recognizing cell-bound co-receptors CCR5 and CXCR4 and infecting cells. Viral selection of CCR5 is associated with the early stages of infection, and transition to selection of CXCR4 indicates disease progression. We have developed a predictive statistical model for co...