BACKGROUND Contradictory results on the efficacy of pindolol associated with selective serotonin reuptake inhibitors (SSRIs) in depressive illness have been published and no former review has produced an overall figure of its efficacy. This study aims to review the efficacy and tolerability of pindolol plus SSRIs in depressive illness. METHODS A meta-analysis of randomised controlled trials (...

Obsessive-compulsive disorder (OCD) is a disabling psychiatric condition affecting 1-2% of the community. Although modern drug, behavioral and psychosurgical therapies have improved the prognosis of OCD considerably, approximately 30% of patients remain treatment-refractory. Currently, selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the drug treatments of choice for OCD. Accordingly,...

Pharmacological management of depressed patients has often relied upon the use of agents that are toxic when taken in large quantities. The recent introduction of selective serotonin reuptake inhibitors (SSRIs) has represented a major advance in the management of depression. While a 'serotonin syndrome' may develop if these drugs are taken in association with other agents, these drugs are belie...

High doses of antidepressants, particularly clomipramine and selective serotonin reuptake inhibitors (SSRIs), are the well-established treatment for obsessive-compulsive disorder (OCD), but manic/hypomanic episodes potential adverse events associated with this treatment. A systematic literature review was performed on in non-bipolar OCD patients. Clinical, sociodemographic antidepressant charac...

Abstract Background Depression and treatment with antidepressant medication is common in patients malignant glioma. However, the extent to which antidepressants may affect disease not fully understood. Therefore, purpose of present study was investigate possible associations between survival glioma patients. Methods We performed a registry-based cohort including 1231 (WHO grades 2, 3, 4) having...

Mice unable to synthesize norepinephrine (NE) and epinephrine due to targeted disruption of the dopamine beta-hydroxylase gene, Dbh, were used to critically test roles for NE in mediating acute behavioral changes elicited by different classes of antidepressants. To this end, we used the tail suspension test, one of the most widely used paradigms for assessing antidepressant activity and depress...

OBJECTIVE To systematically review evidence of the treatment benefits of selective serotonin reuptake inhibitors (SSRIs) for symptoms related to severe premenstrual syndrome (PMS) and premenstrual dysphoric disorder. DATA SOURCES We conducted electronic database searches of MEDLINE, Web of Science, Cochrane Library, Embase, PsycINFO, and Cinahl through March 2007, and hand-searched reference ...

Selective serotonin reuptake inhibitors (SSRIs) have been observed to drive programmed cell death in Burkitt lymphoma cells. Further studies, however, showed that SSRIs induce apoptosis with little, if any, appreciable selectivity. Actually, the selectivity appears to be so low that SSRIs can kill protozoa such as Trichomonas vaginalis. Although the serotonin transporter SERT was initially cons...

OBJECTIVE To summarize remission rates and dropouts due to adverse drug reactions (ADRs) or lack of efficacy (LoE) of serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin-reuptake inhibitors (SSRIs), and tricyclic antidepressants (TCAs) in treating major depressive disorder. METHODS We searched MEDLINE, EMBASE, IPA, and the Cochrane International Library from 1980-2005. M...