Epilepsy is a neurological disorder with prevalence of about 1-2% of the world’s population (Mormann, Andrzejak, Elger & Lehnertz, 2007). It is characterized by sudden recurrent and transient disturbances of perception or behaviour resulting from excessive synchronization of cortical neuronal networks; it is a neurological condition in which an individual experiences chronic abnormal bursts of ...

− Levetiracetam is a novel antiepileptic drug (AED) with proven efficacy against partial seizures, but there is limited information about its effectiveness against generalized seizures. In animal models, levetiracetam protects against seizures in audiogenic susceptible rodents, and it is effective in the Genetic Absence Epilepsy Rat from Strasbourg, a model of absence seizures. In these models,...

BACKGROUND A responsive electrical stimulation pattern based on our recently developed novel seizure prediction method was designed to suppress the penicillin-induced epileptic seizures. METHODOLOGY Seizures were induced by Penicillin injection at rat cortex. A responsive electrical stimulation system was triggered prior to seizures predicted with phase synchronisation. Rats with induced seiz...

this report details the presence of hyperammonemia in a patient who sustained cardiac arrest after a traumatic amputation. serum ammonia levels may rise due to numerous etiologies; however, few reports detail its usefulness in diagnosing subclinical seizures. in this case, we successfully utilized persistently elevated serum ammonia levels as a marker of subclinical seizures in a patient who su...

The usefulness of post-ictal serum prolactin changes, as an adjunct, in the differentiation of generalized tonic-clonic seizures and complex partial seizures from hysterical pseudoepileptic seizures, was investigated in a double blind study designed to control for variables known to alter prolactin levels. Significant post-ictal hyper-prolactinemia, with a peak at 20 minutes and a fall towards ...

A review of patients with epilepsy showed that 5.9% had seizures exclusively in sleep (ES) and 4.7% had seizures predominantly but not exclusively in sleep (PS). These groups were compared with a group (W) with seizures mainly in wakefulness. The following significant differences were obtained: 1) generalized convulsions predominated in the ES while partial seizures were more common among PS an...

This article reviews the ictal and interictal EEG findings associated with a select group of generalized seizures. These include absence seizures, myoclonic seizures seen in juvenile myoclonic epilepsy, idiopathic generalized tonic clonic seizures, infantile spasms, and atypical absence, tonic, and atonic seizures associated with the Lennox Gastaut syndrome.