Kidneys have long been recognized as a major source of plasminogen activators (PAs). However, neither the sites of synthesis of the enzymes nor their role in renal function have been elucidated. By the combined use of zymographies on tissue sections and in situ hybridizations, we have explored the cellular distribution of urokinase-type (u-PA) and tissue-type (t-PA) plasminogen activators and o...

The purpose of this paper was twofold: firstly to measure and partially validate the rates of work done (powers) by the joint reaction forces and moments on the leg segments and secondly to explain the changes in mechanical energy of the segments by the transfer, generation or absorption of energy by the muscles and/or the transfer of energy through the joints. Measurement of the powers require...

We investigated how the velocity of anterior-posterior movement of a visual surround affected segmental kinematics during stance. Ten healthy young adults were exposed to sinusoidal oscillation of an immersive virtual scene at five peak velocities ranging from 1.2 to 188 cm/s at each of four frequencies: 0.05, 0.1, 0.2 and 0.55 Hz. Root mean square (RMS) values of head, trunk, thigh and shank a...

Despite the prevalence of obesity, how obesity affects human physical capabilities is not well documented. As an effort toward addressing this, the current study investigated the obesity effect on joint range of motion (RoM) based on data collected from 20 obese and 20 non-obese males. In total, 30 inter-segmental motions occurring at the shoulder, elbow, knee and ankle joints and lumbar and ce...

Segmental neurological modulation, neural hysteresis and biomechanical effects have been proposed as mechanisms underpinning the effects of manual therapy. An increasing number of studies hypothesise activation of the central nervous system resulting in a non-segmental hypoalgesic effect with concurrent activation of other neural pathways as a potential mechanism of action. Whether this model i...

Cold lesion injury applied to mouse brain and infusion of hyperosmolar L(+) arabinose solution into rat carotid artery were used as extravascular and intravascular insults, respectively, leading to blood-brain barrier (BBB) disruption. To study the cellular mechanisms of the BBB opening, heterologous (bovine) and homologous (mouse and rat) albumin-gold complexes were used as a macromolecular tr...

considerations on the explosion resistant design of special infrastructures have increased in the recent years. amongst the various types of infrastructures, road and railway tunnels have a unique importance due to their vital role in connection routes in emergency conditions. in this study, the explosion effects of a projectile impacting on a railway tunnel located in a jointed rock medium has...

With the attitude adjustment of shield machine, jack thrust angle will change and may lead to great damage segmental lining structures. In this paper, a three-dimensional refined finite element method is proposed study action mechanism influence on mechanical characteristics tunnel, considering additional constrained boundaries formed by various construction loads. Firstly, established verified...

In this study of 38 patients, we assessed the clinical result following surgical treatment of Dupuytren's disease with isolated fifth ray involvement, particularly with respect to the proximal interphalangeal joint. Three surgical techniques were used: limited fasciectomy, segmental fasciectomy and dermofasciectomy. At a mean follow-up time of 53.6 months, there were no residual deformities nor...

The discharge of groundwater and the load on lining structure are both significantly impacted by obstruction tunnel drainage system. In this study, fluid–structure interaction model was established based finite difference software FLAC3D. Then, research explored effects symmetric asymmetric blockage in circular drainpipe, transverse drainpipe at pipe joint pore water pressure, displacement stre...