Aim This retrospective observational study evaluates the safety and efficacy of intravenous sedation using midazolam only or combinations two three drugs including propofol alfentanil for complex dental surgery such as implant placement sinus augmentations. Methods The analyses 60 patients aged 42–79 who required advanced techniques oral procedures. Twenty had (M), 10 a 2-drug combination (MP) ...

Cardiospermum halicacabum used in Ayurveda has been investigated for various pharmacological actions in a number of experimental animal models. On central nervous system the decoction of the plant showed sedative effect. It exhibited significant analgesic and anti-inflammatory activities. The drug also showed vasadepressant activity which is considered to be transcient in nature. In vitro studi...

The sedative and toxic properties of morphine, and five semi-synthetic opiates (diamorphine, dihydromorphinone, dihydrocodeine, oxymorphone and oxycodone) have been determined by giving them, in a double-blind trial, as pre-anaesthetic medication to a standard female population. Diamorphine and dihydromorphinone produced the best sedation whilst dihydrocodeine was least efficient in this respec...

There is no question that the number of women using and abusing nonnarcotic drugs far exceeds the number who are addicted to narcotics (Chambers and Hart 1977). Current data show that 63% to 93.5% of women use analgesics during pregnancy and that sedative drug use ranges from 22% to 28% (Doering and Stewart 1978; Forfar and Nelson 1973; Hill 1973). However, until recently, little attention has ...

Much interest has been focused on the use of midazolam (Versed~Roche Laboratories of Hoffman LaRoche, Nutley, NJ) for conscious sedation in pediatric dentistry. The drug has been used as a preanesthetic sedative in adults and more recently in children. However, studies are lacking concerning its use in pediatric dentistry. The purpose of this paper is to review the pharmacokinetics of midazolam...

Methagoalone, a relatively new sedative hypnotic dmg in the United States, has unique prop& which make the handling of overdosage somewhat different from the stnndard procedures. We report the case of a 20-y&d woman who ingested a large quantity of the drug and required ambat ion and artificial ventilation during the c o w of her recovery. The paper recounts the &tells of thb treatxwnt and revi...

The causes of Stevens-Johnson syndrome (SJS) can be categorized as iatrogenic, infectious or idiopathic. Drug-induced SJS is associated with various antibiotics, anticonvulsants, and other drugs. However, no previous reports have mentioned an association between chlordiazepoxide, a benzodiazepine sedative, and SJS. Here, we present a case of SJS induced by chlordiazepoxide overdose. This case r...

In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads. Amongst the reported metabolites to display such activities was 5-bromo-N,N-dimethyltryptamine. Owing to the importance of the judicious introduction of halogens into drug candidat...

Few medications are as infamous as thalidomide: in the late 1950’s the drug, prescribed to pregnant women as a mild sedative and morning sickness remedy, caused severe congenital malformations in tens of thousands of newborns. The case had significant ramifications for the drug industry, with agencies around the world, including the U.S. Food and Drug Administration, restructuring their rules f...