Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues. We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type th...

The plasticity of cancer cells and the fluidity of the tumor microenvironment continue to present major challenges in the comprehensive understanding of cancer that is essential to design effective treatments. The tumor interstitial fluid (TIF) encompasses the secretome and holds the key to several of the phenotypic characteristics of cancer. Difficulties in sampling this fluid have resulted in...

The genome sequence of Tricholoma vaccinum was obtained to predict its secretome in order to elucidate communication of T. vaccinum with its host tree spruce (Picea abies) in interkingdom signaling. The most prominent protein domains within the 206 predicted secreted proteins belong to energy and nutrition (52%), cell wall degradation (19%) and mycorrhiza establishment (9%). Additionally, we fo...

Plasmodium falciparum is the causative agent of deadly malaria disease. It is an intracellular eukaryote and completes its multi-stage life cycle spanning the two hosts viz, mosquito and human. In order to habituate within host environment, parasite conform several strategies to evade host immune responses such as surface antigen polymorphism or modulation of host immune system and it is mediat...

Helminths are the largest and most complex pathogens to invade and live within the human body. Since they are not able to outpace the immune system by rapid antigen variation or faster cell division or retreat into protective niches not accessible to immune effector mechanisms, their long-term survival depends on influencing and regulating the immune responses away from the mode of action most ...

The oomycetes form a phylogenetically distinct group of eukaryotic microorganisms that includes some of the most notorious pathogens of plants. Oomycetes accomplish parasitic colonization of plants by modulating host cell defenses through an array of disease effector proteins. The biology of effectors is poorly understood but tremendous progress has been made in recent years. This review classi...

Objective: The purpose of this review literature is to look at the mechanism mesenchymal stem cell secretome in regeneration periodontal tissue.Methods: This was collected from several journals and research that has been done, where application Mesenchymal cells (MSCs) promises a favourable result for cell-based therapy inflammatory diseases, immune system disorders, regeneration, tissue repair...

Introduction. Improving treatments for tendon injuries remains a topical issue in biology and medicine. Tendon structure is predisposed to scar formation, with significant regions of dystrophy leading chronic recurrent tendinitis. Stem cell regenerative therapy including mesenchymal stromal secretome among promising improve patient outcomes. Standardized cytokine concentrations can be incorpora...

Collective cell migration is a key feature of transition ductal carcinoma in situ (DCIS) to invasive (IDC) among many other cancers, yet the microenvironmental factors and underlying mechanisms that trigger collective remain poorly understood. Here, we investigated two factors, tumor-intrinsic hypoxia tumor-secreted (secretome), as triggers using three-dimensional (3D) discrete-sized microtumor...

UNLABELLED Secretion of bioactive mediators regulates cell interactions with the microenvironment in tissue homeostasis and wound healing processes. We assessed the cardiomyocyte secretory response to hypoxia with the aim of identifying key mediators of tissue pathology and repair after ischemic heart attack. We profiled the secretome of rat H9C2 cardiomyoblast cells subjected to 16h hypoxia fo...