Submit Manuscript | http://medcraveonline.com Abbreviations: TCR: γδT Receptor; RE: Rasmussen’s Encephalitis; CD: Cortical Dysplasia; APCs: Antigen Presenting Cells; MS: Multiple Sclerosis; BBB: Blood Brian Barrier; GBM: Glioblastoma Multiforme; MGMT: Methylguanine Methyltransferase; NK: Natural Killer; WNV: West Nile virus RR: Relapsing Remitting; PP: Primary Progressive; SP: Secondary Progres...

Multiple sclerosis (MS) is a chronic, autoimmune disease affecting the central nervous system. The disease targets the myelin sheaths around nerves, leading to inflammation, myelin loss, and axonal destruction. MS is the most common cause of neurologic disability in people between the ages of 20 and 40. There are approximately 400,000 cases of MS in North America and approximately 2.5 million w...

BACKGROUND Registry to Evaluate Novantrone Effects in Worsening Multiple Sclerosis (RENEW) was a 5-year, phase IV study in which the safety of Mitoxantrone was monitored in a patient cohort from the United States (US). The objective of the study was to evaluate the long-term safety profile of Mitoxantrone in patients with secondary progressive multiple sclerosis (SPMS), progressive relapsing mu...

multiple sclerosis (ms) is a demyelinating disease of the central nervous system, with unknown etiology in which both genetic and environmental factors are thought to be involved. the human leukocyte antigen (hla) system provides a set of genetic markers which lend themselves to systematic study. in iran, hla-a24, hla-dr2, and hla- dr15 are significantly increased in ms patients. the disease al...

CONTEXT Hypointense lesions on T1-weighted spin-echo magnetic resonance images (T1 lesions) represent destructive multiple sclerosis (MS) lesions, consisting of axonal loss and matrix destruction. These lesions are being used as a secondary outcome measure in phase III clinical trials. Clinical determinants of T1 lesions may differ between subgroups of patients with MS and subsequently may have...

Long TR and gadolinium enhanced spin echo brain MRI was performed weekly for three months in three patients with relapsing-remitting or secondary progressive multiple sclerosis. During the study, 38 new enhancing lesions were seen; 11 showed enhancement for less than four weeks, and two enhanced on only one scan. All 16 new lesions seen on long TR scans showed initial enhancement. When only eve...

OBJECTIVE To evaluate concurrent and predictive validity for low-contrast letter acuity (L-CLA) testing as a candidate visual component for the Multiple Sclerosis Functional Composite (MSFC). METHODS L-CLA testing was conducted in two MS patient cohorts. In the MSFC Validation Study, 137 participants from a Phase III trial of inteferon beta-1a (Avonex) for relapsing-remitting MS were followed...

Background & Aims: Substance abuse may have different effects on multiple sclerosis. Till now, studies on substance abuse and its correlation with psychopathology, type and severity of multiple sclerosis are limited. We conducted this study to evaluate the psychopathology of patients with multiple sclerosis with and without substance abuse. Methods: In this case-control, cross-sectional study p...

conclusions our study suggests that the personality traits of patients with ms and healthy individuals are not significantly different. patients with ms are likely to use the same coping strategies as healthy individuals, except in the subscale of distancing. results no significant differences in personality characteristics were observed between patients and healthy controls (all p > 0.05). onl...