Although the excellent review on the contact system by Colman and Schmaier1 that appeared recently in Blood examines the subject in great detail, there are some points that deserve further discussion. A major item in that review is the novel observation, described recently in Blood,2 that prekallikrein (PK) becomes activated when it is bound to high molecular weight kininogen (HK) on endothelia...

EDITOR: Factor XII deficiency is a hereditary state that is usually discovered because of an unexpected prolongation of activated partial thrombin time (aPTT) during preoperative evaluation. We report the perioperative management of an orthopaedic patient with severe factor XII deficiency. An 18-yr-old male (height: 175 cm, weight: 72 kg) with a lateral malleolar fracture was transferred to our...

A new type of cosmic-ray experiment is under construction in the Pyhäsalmi mine in the underground laboratory of the University of Oulu, Finland. It aims to study the composition of cosmic rays at and above the knee region. The experiment, called EMMA, will cover approximately 150 m of detector area. The array is capable of measuring the multiplicity and the lateral distribution of underground ...

In this issue of Blood, MacQarrie and colleagues show that histidine-rich glycoprotein (a negative acute-phase reactant), inhibits activated factor XII, a clotting protein implicated in inflammation and thrombosis.1 O f the 2 mechanisms for triggering blood clotting, only the tissue factor pathway is essential for normal hemostasis. The other— the contact pathway—appears to have no hemostatic r...

In obstructive sleep apnea patients, upper airway muscle tone is depressed during rapid eye movement (REM) sleep parallel to the characteristic postural atonia. Previous electrophysiological, pharmacological and anatomical studies provided evidence that a withdrawal of excitation mediated by norepinephrine and serotonin as well as active inhibition may contribute to the REM sleep-related depres...

The Burr type XII has been studied for various applications of lifetime modelings. However, control charts related to the Burr type XII percentiles have not been seen in the literature. In this paper, three control charts for the Burr type XII percentiles are investigated. An extensive Monte Carlo simulation study is conducted to compare among the Shewhart-type chart, and parametric bootstrap c...

Web servers such as Apache and web proxies like Squid support event logging using a common log format. The logs produced using these de-facto standard formats are invaluable to system administrators for trouble-shooting a server and tool writers to craft tools that mine the log files and produce reports and trends. The Session Initiation Protocol (SIP) does not have a common log format, and as ...

HOLCOMBE (2004) ARGUED THAT government was inevitable. In Block (2005) I maintained that this institution was not unavoidable. Holcombe (2007) takes issue with that response of mine to his earlier paper, and the present essay is, in turn, a response to his latest missive in this conversation.1 In section I, I deal with what I can consider an anomaly in Holcombe’s argument. Section II is devoted...

Different power quality (PQ) disturbance sources can have major impacts on the power supply grid. This study proposes, for the first time, an early warning approach to identifying PQ problems and providing early warning prompts based on the monitored data of PQ disturbance sources. To establish a steady-state power quality early warning index system, the characteristics of PQ disturbance source...

Well-known web servers such as Apache and web proxies like Squid support event logging using a common log format. The logs produced using these de facto standard formats are invaluable to system administrators for troubleshooting a server and tool writers to craft tools that mine the log files and produce reports and trends. Furthermore, these log files can also be used to train anomaly detecti...