Microautoradiography was employed to show that association of drugs from the serum directly with forming hair pigment is a primary pathway of deposition into the hair. After systemic administration of [3H]flunitrazepam, [3H]nicotine, and [3H]cocaine, association of all three drugs with melanin in the forming hair was observed within minutes of dosage. Sebum was determined to be an insignificant...

Sebum is a well-recognised protection of the skin and minor changes on its composition quantity impact homeostasis. Over production induces microbiota dysbiosis in favor C. acnes proliferation leading to homeostasis dysbalance. Mangifera indica extract was traditionnaly used folk medicine for antibacterial antioxidant properties. In vitro studies demonstrated that main phytomarker identified, m...

Skin is the primary interface with external environment. To evaluate impact of factors like sun exposure on cutaneous ecosystem (skin-sebum-microbiota), it has to be studied as a whole understand how they interact each other. We developed reconstructed human epidermal model colonized microbiota and sebum reproduce complexity skin ecosystem. This in vitro was exposed simulated solar radiation (S...

Background: The weakened keratinocyte cohesion, wrinkle formation, loss of elasticity, decreased sebum production, increased water loss, and other skin problems caused by a compromised barrier can eventually result in various diseases. Given its current usage as disinfectant potential use medicine, it is crucial to assess the safety chlorinated water. Objective: study’s objective was evaluate l...

Abstract Background Age‐related changes in scalp parameters affect hair quality and condition. However, detailed data on biophysical of the across age groups remain scarce. We aimed to investigate differences between individuals their 20s 50s analyze sex‐specific variations. Materials methods Two hundred participants (160 women 40 men) were equally divided into groups. Biophysical scalp, includ...

Abstract Acne vulgaris is a common disease of the pilosebaceous unit. Hyperseborrhea, follicular colonization by Cutibacterium acnes and complex inflammatory state are pathogenic factors acne vulgaris. In present study we investigated anti-acne efficacy Castanea crenata bur extract (CBE) in vitro searched active compound for mitigating hyperseborrhea. sebocytes, CBE inhibited sebum synthesis th...