Bladder cancer has been cited to result from the neoplastic lesion with environmental and/or occupational factors identified as causatives. Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Most of the bladder cancer patients die from the invasive, metastatic TCC that has turned out to be resistant to chemotherapy. T24 cells, a cell line established from a human urina...

Objective: Kaempferol is a natural flavonol found in many dietary fruits, vegetables, and medicinal herbs. It reportedly has multiple beneficial properties as analyzed in vivo and in vitro. The objective of this study was to determine cytoprotective, anti-inflammatory, and wound healing characteristics of kaempferol in cultured human gingival fibroblasts. Materials & Methods: To determine cytot...

PURPOSE Human tissue Factor Pathway Inhibitor-2 (TFPI-2) is a potent inhibitor of plasmin, which activates metalloproteinases involved in extracellular matrix degradation. Its secretion in the extracellular matrix makes TFPI-2 a potential inhibitor of tumor cell invasion. However, no studies have yet evaluated the wound-healing activities of human Tenon's capsule fibroblasts (hTCFs). The aim of...

In order to identify novel targets for the molecular therapy of gastric cancer (GC), we investigated the mRNA and protein expression of frizzled-2 (Fz2), a Wnt signaling pathway receptor. Reverse-transcriptase polymerase chain reaction (PCR) amplification was utilized to determine the expression patterns of Fz genes in normal stomach and in the GC cell lines MKN45 and MKN74. Immunostaining was ...

In this paper we present the feature of Dr. Scratch that allows to automatically assessing the Computational Thinking skills of Scratch projects. The paper reviews similar initiatives, like Hairball, and investigates the literature with proposals for assessment of Scratch projects that we have studied and remixed in order to develop the Computational Thinking analysis. Then it introduces the va...

Abstract In the course of identifying molecular mechanism that is related to strong cell‐cell adhesion in stratified structures squamous epithelium, calmodulin‐like protein 5 (CALML5) was identified as a spinous structure‐associated by producing monoclonal antibodies with use crude intercellular portion tissue an immunogen and subsequent morphologic screening. By electrophoretic mobility shift ...

Abstract The plant Stryphnodendron adstringens is a species of legume in the genus that found Brazil. It also known as “barbatimão-verdadeiro” and it popularly used folk medicine due to its healing properties. Purpose: aim this study was evaluate activity hydrogel, together with an S. hydroalcoholic extract, diabetic non-diabetic rats. Methods: phytochemical analysis extract evaluated through H...

Background: Esophageal cancer is one of the primary death causes leading by in world, which high morbidity and mortality. Epigenetic acetylation modification participates regulates proliferation, invasion, metastasis various tumor cells, proteins involved acetyltransferases may be important mechanisms esophageal carcinogenesis. The aim this study was to investigate correlation acetyltransferase...

Functionalized hydrogels stimulate the migration and morphogenesis of endothelial cells (ECs) are useful substrates for wound healing. The present study investigates feasibility covalent conjugation taurine (Tau) on a gelatin-based hydrogel. This hydrogel is expected to maintain positive charged growth factors such as basic fibroblast factor (bFGF) vascular (VEGFs) near ECs within microenvironm...